PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25855965-1	2015	We previously reported that IL-2 deprivation induced acid sphingomyelinase-mediated (ASM-mediated) ceramide elevation and apoptosis in an NK/T lymphoma cell line KHYG-1.	Ceramides	99-107	H19 imprinted maternally expressed transcript	Homo sapiens	85-88	
25855965-5	2015	However, IL-2 deprivation induced ceramide elevation via ASM in lysosomes and activated lysosomal cathepsin B (CTSB) but not cathepsin D.	Ceramides	34-42	H19 imprinted maternally expressed transcript	Homo sapiens	57-60	
25855965-7	2015	Inhibition of ceramide accumulation in lysosomes using an ASM inhibitor, desipramine, decreased cytosolic activation of CTSB by inhibiting its transfer into cytosol from the lysosome.	Ceramides	14-22	H19 imprinted maternally expressed transcript	Homo sapiens	58-61	
25855965-10	2015	These findings suggest that lysosomal ceramide produced by ASM mediates XIAP degradation by activation of cytosolic CTSB and caspase-dependent apoptosis.	Ceramides	38-46	H19 imprinted maternally expressed transcript	Homo sapiens	59-62	
25855965-11	2015	The ASM-ceramide-CTSB signaling axis is a novel pathway of ceramide-mediated apoptosis in IL-2-deprived NK/T lymphoma cells.	Ceramides	8-16	H19 imprinted maternally expressed transcript	Homo sapiens	4-7	
25855965-11	2015	The ASM-ceramide-CTSB signaling axis is a novel pathway of ceramide-mediated apoptosis in IL-2-deprived NK/T lymphoma cells.	Ceramides	59-67	H19 imprinted maternally expressed transcript	Homo sapiens	4-7	
19834551-5	2009	Ceramides induced by MV, but also bacterial sphingomyelinase, efficiently interfered with formation of membrane protrusions and T cell spreading and front/rear polarisation in response to beta1 integrin ligation or alphaCD3/CD28 activation, and this was rescued upon pharmacological or genetic ablation of ASM/NSM activity.	Ceramides	0-9	H19 imprinted maternally expressed transcript	Homo sapiens	306-309	
29076348-1	2017	AIM: ASM, which hydrolyzes sphingomyelin into ceramide, is recognized as a therapeutic target for UV-induced skin damage.	Ceramides	46-54	H19 imprinted maternally expressed transcript	Homo sapiens	5-8