PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17548428-3	2007	Then roles and mechanisms of action of ceramide-mediated deacetylation of Sp3 in inhibiting the hTERT promoter were determined using constitutively deacetylated or acetylated Sp3 mutants at lysine (K) 551.	Ceramides	39-47	telomerase reverse transcriptase	Homo sapiens	96-101	
23830072-4	2013	hTERT upregulation was accompanied by recruitment of ceramide, a known regulator of hTERT, to the chlamydial inclusion and was abrogated following doxycycline-mediated infection clearance.	Ceramides	53-61	telomerase reverse transcriptase	Homo sapiens	0-5	
23830072-4	2013	hTERT upregulation was accompanied by recruitment of ceramide, a known regulator of hTERT, to the chlamydial inclusion and was abrogated following doxycycline-mediated infection clearance.	Ceramides	53-61	telomerase reverse transcriptase	Homo sapiens	84-89	
15951564-1	2005	In this study, the roles of Sp1/Sp3 transcription factors in the regulation of the activity of human telomerase reverse transcriptase (hTERT) promoter in response to ceramide were examined in the A549 human lung adenocarcinoma cells.	Ceramides	166-174	telomerase reverse transcriptase	Homo sapiens	101-133	
15951564-1	2005	In this study, the roles of Sp1/Sp3 transcription factors in the regulation of the activity of human telomerase reverse transcriptase (hTERT) promoter in response to ceramide were examined in the A549 human lung adenocarcinoma cells.	Ceramides	166-174	telomerase reverse transcriptase	Homo sapiens	135-140	
15951564-2	2005	The activity of the N-terminal truncated hTERT promoter, lacking the c-Myc recognition (E-box) region but containing multiple Sp1/Sp3 sites, was also significantly inhibited by C6-ceramide, indicating a role for ceramide in the regulation of Sp1/Sp3 function.	Ceramides	180-188	telomerase reverse transcriptase	Homo sapiens	41-46	
15951564-5	2005	The interaction between Sp1 and hTERT promoter DNA was significantly reduced in response to ceramide as assessed by chromatin immunoprecipitation analysis.	Ceramides	92-100	telomerase reverse transcriptase	Homo sapiens	32-37	
15951564-9	2005	The roles of endogenous long chain ceramide generated in response to gemcitabine in the inhibition of hTERT promoter activity and the regulation of Sp3 acetylation were also demonstrated.	Ceramides	35-43	telomerase reverse transcriptase	Homo sapiens	102-107	
14592454-7	2003	Mechanistically, inhibition of telomerase by endogenous ceramide in response to ATRA treatment involves, at least in part, down-regulation of the expression of telomerase reverse transcriptase (hTERT) mRNA, as determined by semi-quantitative RT-PCR, in these cells.	Ceramides	56-64	telomerase reverse transcriptase	Homo sapiens	194-199	
11441001-8	2001	Taken together, these results show for the first time that both exogenous and endogenous ceramides mediate the modulation of telomerase activity via decreased hTERT promoter activity caused by rapid proteolysis of the ubiquitin-conjugated c-Myc transcription factor.	Ceramides	89-98	telomerase reverse transcriptase	Homo sapiens	159-164	
11441001-4	2001	Electrophoretic mobility shift and supershift assays demonstrated that the binding activity of c-Myc transcription factor to the E-box sequence on the hTERT promoter was inhibited in response to C(6)-ceramide at 24 h. These results were also confirmed by transient transfections of A549 cells with pGL3-Basic plasmid constructs containing the functional hTERT promoter and its E-box deleted sequences cloned upstream of a luciferase reporter gene.	Ceramides	200-208	telomerase reverse transcriptase	Homo sapiens	151-156	
11441001-4	2001	Electrophoretic mobility shift and supershift assays demonstrated that the binding activity of c-Myc transcription factor to the E-box sequence on the hTERT promoter was inhibited in response to C(6)-ceramide at 24 h. These results were also confirmed by transient transfections of A549 cells with pGL3-Basic plasmid constructs containing the functional hTERT promoter and its E-box deleted sequences cloned upstream of a luciferase reporter gene.	Ceramides	200-208	telomerase reverse transcriptase	Homo sapiens	354-359	
11441001-7	2001	Furthermore, the elevation of endogenous ceramide by overexpression of bacterial sphingomyelinase after transient transfections also induced the inhibition of telomerase activity with concomitant decreased hTERT and c-Myc protein levels.	Ceramides	41-49	telomerase reverse transcriptase	Homo sapiens	206-211