PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22129459-8	2012	Thus it is likely that during cellular stress, disassembly of Golgi structure together with inactivation of CERT by caspases causes a reduction in ceramide trafficking and SM synthesis, and could contribute to the cellular response to pro-apoptotic stress.	Ceramides	147-155	caspase 2	Homo sapiens	116-124	
26727221-0	2016	Glycogen Synthase Kinase-3beta and Caspase-2 Mediate Ceramide- and Etoposide-Induced Apoptosis by Regulating the Lysosomal-Mitochondrial Axis.	Ceramides	53-61	caspase 2	Homo sapiens	35-44	
26727221-8	2016	These results demonstrate the importance of GSK-3beta and caspase-2 in ceramide- and etoposide-induced apoptosis through mechanisms involving Mcl-1 destabilization and the lysosomal-mitochondrial axis.	Ceramides	71-79	caspase 2	Homo sapiens	58-67	
29621545-3	2018	Further, stable suppression of caspase-2 expression in HEK293T and HeLa cells enabled a systematic investigation of putative novel enzyme functionalities, especially with respect to ceramide production, cell migration, IL-6 production and vesicular homeostasis, all of which have been previously reported to be associated with FAN.	Ceramides	182-190	caspase 2	Homo sapiens	31-40	
17666435-8	2007	These results indicate a role for GSK-3beta in ceramide-induced apoptosis, in which GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 and caspase-8.	Ceramides	47-55	caspase 2	Homo sapiens	167-176	
17666435-0	2007	GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis.	Ceramides	96-104	caspase 2	Homo sapiens	83-92	
17666435-5	2007	We previously reported that ceramide induced caspase-2 and caspase-8 activation, Bid cleavage, mitochondrial damage, and apoptosis.	Ceramides	28-36	caspase 2	Homo sapiens	45-54	
10747891-2	2000	The early generation of ceramide preceded transient activation of acidic ceramidase and subsequent production of sphingosine, followed by cytochrome c release, activation of caspases-2, -3, -6, -7, -8, and -9, Bid cleavage, and a later sustained ceramide accumulation.	Ceramides	24-32	caspase 2	Homo sapiens	174-208	
15817479-0	2005	Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation.	Ceramides	14-22	caspase 2	Homo sapiens	90-99	
15817479-4	2005	Stress stimuli, including ceramide and etoposide, caused caspase-2 activation, mitochondrial damage followed by downstream caspase-9 and -3 activation, and cell apoptosis in human lung epithelial cell line A549.	Ceramides	26-34	caspase 2	Homo sapiens	57-66	
15817479-6	2005	Overexpression of Bcl-2 prevented ceramide- and etoposide-induced caspase-2 activation and mitochondrial apoptosis.	Ceramides	34-42	caspase 2	Homo sapiens	66-75	
15817479-12	2005	Taken together, ceramide and etoposide induced mitochondria-mediated apoptosis by initiating caspase-2 activation, which was, at least in part, regulated by Bcl-2.	Ceramides	16-24	caspase 2	Homo sapiens	93-102	
15746654-13	2005	These data demonstrate that endogenous ceramide generation and subsequent phosphatase activation during apoptosis are key steps in the alternative splicing of caspase-2 mRNA and further suggest a link between the signal-transduction pathway and alternative splicing.	Ceramides	39-47	caspase 2	Homo sapiens	159-168	
15262979-4	2004	Here we report a potential regulatory role of caspase-2 on caspase-8 during ceramide-induced apoptosis.	Ceramides	76-84	caspase 2	Homo sapiens	46-55	
15262979-7	2004	Ceramide-induced caspase-8 activation, mitochondrial damage, and apoptosis were blocked in caspase-2 short interfering RNA-expressing cells.	Ceramides	0-8	caspase 2	Homo sapiens	91-100	
15262979-8	2004	Therefore, caspase-2 acts upstream of caspase-8 during ceramide-induced mitochondrial apoptosis.	Ceramides	55-63	caspase 2	Homo sapiens	11-20	
15262979-10	2004	These data suggest sequential initiator caspase-2 and caspase-8 activation in the mitochondrial apoptotic pathway induced by ceramide or etoposide.	Ceramides	125-133	caspase 2	Homo sapiens	40-49	
10590315-0	1999	Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells.	Ceramides	86-94	caspase 2	Homo sapiens	74-82