PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19458474-1	2009	We unveiled novel p65/RelA consensus sites in the promoter of the beclin 1 gene and demonstrate that p65/RelA positively modulates canonical autophagy in various human cell lines both under basal conditions and upon induction by ceramide.	Ceramides	229-237	beclin 1	Homo sapiens	66-74	
19337026-2	2009	Like amino acid starvation, ceramide triggers autophagy by interfering with the mTOR-signaling pathway, and by dissociating the Beclin 1:Bcl-2 complex in a c-Jun N-terminal kinase 1 (JNK1)-mediated Bcl-2 phosphorylation-dependent manner.	Ceramides	28-36	beclin 1	Homo sapiens	128-136	
19337026-3	2009	Dissociation of the Beclin 1:Bcl-2 complex, and the subsequent stimulation of autophagy have been observed in various contexts in which the cellular level of long-chain ceramides was increased.	Ceramides	169-178	beclin 1	Homo sapiens	20-28	
19337026-5	2009	The dissociation of the Beclin 1:Bcl-2 complex has also been observed in response to tamoxifen and PDMP (an inhibitor of the enzyme that converts ceramide to glucosylceramide), drugs that increase the intracellular level of long-chain ceramides.	Ceramides	146-154	beclin 1	Homo sapiens	24-32	
19337026-5	2009	The dissociation of the Beclin 1:Bcl-2 complex has also been observed in response to tamoxifen and PDMP (an inhibitor of the enzyme that converts ceramide to glucosylceramide), drugs that increase the intracellular level of long-chain ceramides.	Ceramides	235-244	beclin 1	Homo sapiens	24-32	
19337026-7	2009	Whether this autophagy that is unchecked by forced dissociation of the Beclin 1:Bcl-2 complex is related to the ability of ceramide to trigger cell death remains an open question.	Ceramides	123-131	beclin 1	Homo sapiens	71-79	
19060920-10	2009	Chromatin immunoprecipitation and luciferase reporter analysis revealed that c-Jun was involved in the regulation of beclin 1 transcription in response to ceramide treatment.	Ceramides	155-163	beclin 1	Homo sapiens	117-125	
19060920-5	2009	In this study, we used human cancer cell lines CNE2 and Hep3B to investigate the role of JNK-mediated Beclin 1 expression in ceramide-induced autophagic cell death.	Ceramides	125-133	beclin 1	Homo sapiens	102-110	
19060920-8	2009	In the meantime, we found that ceramide upregulated Beclin 1 expression in cancer cells.	Ceramides	31-39	beclin 1	Homo sapiens	52-60	
19029119-3	2009	Here we show that short-chain ceramides (C(2)-ceramide and C(6)-ceramide) and stimulation of the de novo ceramide synthesis by tamoxifen induce the dissociation of the complex formed between the autophagy protein Beclin 1 and the anti-apoptotic protein Bcl-2.	Ceramides	30-39	beclin 1	Homo sapiens	213-221	
19029119-3	2009	Here we show that short-chain ceramides (C(2)-ceramide and C(6)-ceramide) and stimulation of the de novo ceramide synthesis by tamoxifen induce the dissociation of the complex formed between the autophagy protein Beclin 1 and the anti-apoptotic protein Bcl-2.	Ceramides	30-38	beclin 1	Homo sapiens	213-221	
19060920-12	2009	Furthermore, Beclin 1 knockdown by siRNA also inhibited ceramide-mediated autophagic cell death.	Ceramides	56-64	beclin 1	Homo sapiens	13-21	
23230024-2	2013	Through the resultant increase in ceramides which interact with mTOR and Beclin1 (Atg6), this drug is also known to induce macroautophagy in mammalian cells.	Ceramides	34-43	beclin 1	Homo sapiens	73-80	
14970205-0	2004	Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1.	Ceramides	0-8	beclin 1	Homo sapiens	94-102	
23230024-2	2013	Through the resultant increase in ceramides which interact with mTOR and Beclin1 (Atg6), this drug is also known to induce macroautophagy in mammalian cells.	Ceramides	34-43	beclin 1	Homo sapiens	82-86