PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12536246-0 2003 Sestamibi is a substrate for MDR1 and MDR2 P-glycoprotein genes. Technetium Tc 99m Sestamibi 0-9 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 29-33 15967124-2 2005 The positron-emitting radiotracer hexakis(2-methoxyisobutylisonitrile)-(94m)Tc ((94m)Tc-MIBI) was synthesized and validated in cell transport studies as a substrate for MDR1 Pgp. Technetium Tc 99m Sestamibi 85-92 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 169-173 19093112-8 2009 CONCLUSIONS: Quantified (99m)Tc-MIBI efflux has potential to: (1) noninvasively assign Mdr1 expression levels, (2) predict the therapeutic impact of a P-gp inhibitor, and (3) noninvasively assess the probability of drug resistance. Technetium Tc 99m Sestamibi 29-36 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 87-91 17541583-1 2007 PURPOSE: The purpose of this work was the development of an orthotopic model of osteosarcoma based on luciferase-expressing tumour cells for the in vivo imaging of multidrug resistance (MDR) with (99m)Tc-sestamibi. Technetium Tc 99m Sestamibi 201-213 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 186-189 17541583-14 2007 The kinetic analysis of (99m)Tc-sestamibi washout provides information on the functional activity of MDR related to P-glycoprotein expression and its pharmacological inhibition in osteosarcoma. Technetium Tc 99m Sestamibi 29-41 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 101-104 16955376-0 2006 99mTc-Sestamibi, a sensitive probe for in vivo imaging of P-glycoprotein inhibition by modulators and mdr1 antisense oligodeoxynucleotides. Technetium Tc 99m Sestamibi 0-15 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 102-106 16026704-1 2005 BACKGROUND: (99m)Tc-sestamibi (MIBI) and (99m)Tc-tetrofosmin (TF) are avid transport substrates recognized by the multidrug resistance (MDR) P-glycoprotein (Pgp). Technetium Tc 99m Sestamibi 17-29 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 136-139 12536246-6 2003 In double knockout mice lacking both mdr1a and mdr1b homologs of the human MDR1 ( ABCB1) gene, 88%+/-11% of maximal sestamibi activity was retained in the liver after 1 h ( P<0.001). Technetium Tc 99m Sestamibi 116-125 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 47-52 12536246-10 2003 Sestamibi appears to be a substrate for both ABCB1 and ABCB4 genes, although the former utilizes it far more efficiently. Technetium Tc 99m Sestamibi 0-9 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 45-50 21204761-3 2010 Inhibition of P-gp function by MDR1 shRNA and functional activity of hNIS gene was assessed using a 99(m)Tc sestamibi uptake and 125I uptake, respectively. Technetium Tc 99m Sestamibi 108-117 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 31-35