PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24308840-3	2014	Here, we demonstrate that LE135 [4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid], a selective antagonist of RARbeta , is a potent activator of the capsaicin (TRPV1) and wasabi (TRPA1) receptors, two critical pain-initiating cation channels.	LE 135	26-31	transient receptor potential cation channel subfamily A member 1	Homo sapiens	235-240	
24308840-4	2014	EXPERIMENTAL APPROACH: We performed to investigate the excitatory effects of LE135 on TRPV1 and TRPA1 channels expressed in HEK293T cells and in dorsal root ganglia neurons with calcium imaging and patch-clamp recordings.	LE 135	77-82	transient receptor potential cation channel subfamily A member 1	Homo sapiens	96-101	
24308840-5	2014	We also used site-directed mutagenesis of the channels to determine the structural basis of LE135-induced activation of TRPV1 and TRPA1 channels and behavioural testing to examine if pharmacological inhibition and genetic deletion of the channels affected LE135-evoked pain-related behaviours.	LE 135	92-97	transient receptor potential cation channel subfamily A member 1	Homo sapiens	130-135	
24308840-6	2014	KEY RESULTS: LE135 activated both the capsaicin receptor (TRPV1) and the allyl isothiocyanate receptor (TRPA1) heterologously expressed in HEK293T cells and endogenously expressed by sensory nociceptors.	LE 135	13-18	transient receptor potential cation channel subfamily A member 1	Homo sapiens	104-109	
24308840-9	2014	Both TRPV1 and TRPA1 channels were involved in LE135-elicited pain-related responses, as shown by pharmacological and genetic ablation studies.	LE 135	47-52	transient receptor potential cation channel subfamily A member 1	Homo sapiens	15-20