PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31296984-8	2019	In addition, TP markedly induced apoptosis in MLTC-1 cells via increasing the expressions of Bax, active caspase 3, Cyto c and active caspase 9, and decreasing the level of Bcl-2.	triptolide	13-15	caspase 3	Mus musculus	105-114	
15184078-0	2004	Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation.	triptolide	0-10	caspase 3	Mus musculus	111-120	
15184078-0	2004	Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation.	triptolide	12-18	caspase 3	Mus musculus	111-120	
15184078-6	2004	Triptolide induces activation of p38 in DCs, which precedes the activation of caspase 3.	triptolide	0-10	caspase 3	Mus musculus	78-87	
31774600-6	2020	Also, significant upregulation of Bcl-2 and LC3B expressions, with the downregulation of p62, Bax and caspase-3 expressions were found in TP-treated group.	triptolide	138-140	caspase 3	Mus musculus	102-111	
28892788-8	2017	Moreover, dose-dependent activation of caspase-3 and decreased Bcl2/Bax proportion were observed after triptolide treatment.	triptolide	103-113	caspase 3	Mus musculus	39-48	
28905938-7	2018	The above results from in vitro experiments were further validated in male mice after oral administration of TP (30, 60, and 120 mg kg-1 d-1, for 14 d), as evidenced by the detected indexes, including dose-dependently decreased SDH activity, increased MDA concentration, altered testicle histomorphology, elevated caspase-3 activation, apoptosis induction, increased phosphorylation of JNK, and decreased gene expression of NQO1, CAT and HO-1 as well as nuclear protein expression of Nrf2 in testicular tissue.	triptolide	109-111	caspase 3	Mus musculus	314-323	
29085508-7	2017	Annexin V/propidium iodide staining identified that triptolide promoted apoptosis and western blot analysis confirmed that triptolide activated caspase-3-dependent apoptosis.	triptolide	123-133	caspase 3	Mus musculus	144-153	
29085508-0	2017	Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.	triptolide	0-10	caspase 3	Mus musculus	41-50	
26990902-5	2017	Triptolide increased protein levels of Fas, Fas-L, Bax, cytochrome c, caspase-9, Endo G, Apaf-1, PARP, caspase-3 but reduced levels of AIF, ATF6alpha, ATF6beta, and GRP78 in WEHI-3 cells.	triptolide	0-10	caspase 3	Mus musculus	103-112	
24352031-9	2014	Furthermore, cells treated with triptolide plus chemotherapeutics exhibited marked production of intracellular ROS and caspase-3 activity compared with single treatment, which paralleled the incidence of apoptosis.	triptolide	32-42	caspase 3	Mus musculus	119-128