PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24705868-6	2014	Both effects of beta2-adrenoceptor agonists were mimicked by forskolin, a direct activator of adenylyl cyclase and cholera toxin, which stimulates adenylyl cyclase by permanent activation of Gs.	Colforsin	61-70	adrenoceptor beta 2	Homo sapiens	16-34	
14722251-5	2004	Epinephrine, prostaglandin E1, and forskolin at maximum concentrations stimulated phosphorylation of the beta2AR PKA site (Ser262) by 4-fold, whereas PMA stimulated it by 2-fold.	Colforsin	35-44	adrenoceptor beta 2	Homo sapiens	105-112	
16873402-4	2006	beta(2)AR stimulation increased l-arginine transport, as did cyclic AMP elevation with either forskolin or dibutyryl cyclic AMP, and this increase was inhibitable by N-ethylmaleimide.	Colforsin	94-103	adrenoceptor beta 2	Homo sapiens	0-9	
14662724-11	2004	The desensitisation induced by long-term treatments with salmeterol and formoterol was specific for beta(2)-adrenoceptor-mediated inhibition of histamine release as the inhibitory effects of alternative cAMP-elevating compounds, prostaglandin E(2), a receptor-mediated activator of adenylate cyclase, and forskolin, a direct activator of adenylate cyclase, were unaffected by desensitising treatments.	Colforsin	305-314	adrenoceptor beta 2	Homo sapiens	100-120	
21225244-7	2011	A 5-min treatment with NAD decreased forskolin-stimulated phosphorylation at the beta(2)AR PKA site Ser 262 while a 24-h treatment with NAD increased it.	Colforsin	37-46	adrenoceptor beta 2	Homo sapiens	81-90	
14758043-0	2004	Influence of receptor number on the cAMP response to forskolin in Chinese hamster ovary cells transfected with human beta2-adrenoceptor.	Colforsin	53-62	adrenoceptor beta 2	Homo sapiens	117-135	
9698608-5	1998	Acute heterologous beta2AR desensitization was characterized by an approximately 20% and 30% loss of maximal responsiveness to ISO challenge when cells were pretreated with forskolin and prostaglandin E2 (PGE2), respectively.	Colforsin	173-182	adrenoceptor beta 2	Homo sapiens	19-26	
9295336-9	1997	The two strongest agonists, epinephrine and fenoterol, provoked 11-13-fold increases in the level of betaAR phosphorylation after just 1 min, whereas the weak agonists dobutamine and ephedrine caused only 3-4-fold increases, similar to levels induced by cAMP-dependent protein kinase activation with forskolin.	Colforsin	300-309	adrenoceptor beta 2	Homo sapiens	101-107	
2845534-3	1988	The addition of 10 microM forskolin to 50 microM isoproterenol potentiated isoproterenol induced beta 2 adrenoceptor desensitization as shown by further reduction in [3H]-DHA binding sites (decreased by 40% at 25 degrees C, 45% at 4 degrees C) and corresponding decrease in cyclic AMP responsiveness.	Colforsin	26-35	adrenoceptor beta 2	Homo sapiens	97-116	
7559596-7	1995	Further characterization of this phosphorylation, using either forskolin stimulation or phosphorylation site-deficient beta 2AR-Y326A mutants, demonstrated that the beta 2AR-Y326A mutant can be phosphorylated by cAMP-dependent protein kinase (PKA) but does not serve as a substrate for the beta-adrenergic receptor kinase 1 (beta ARK1).	Colforsin	63-72	adrenoceptor beta 2	Homo sapiens	165-173	
1325962-6	1992	Direct stimulation with forskolin resulted in greater cAMP production in the testosterone-treated myocytes compared to controls, thereby refuting the possibility that testosterone directly suppresses adenylyl cyclase activity at 24 h. These findings suggest that although both testosterone and hydrocortisone produce a twofold increase in beta 2-adrenergic receptor density in the DDT1 myocytes, beta 2-adrenergic receptors expressed in response to hydrocortisone appear functional at 24 h resulting in increased cAMP production, whereas those expressed in response to testosterone require 48 h to demonstrate increased functional activity.	Colforsin	24-33	adrenoceptor beta 2	Homo sapiens	339-365