PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27342398-10 2017 Idelalisib treatment inhibited AKT activation, an immediate downstream PI3K effector, and also reduced phosphorylation levels of downstream AKT/mTOR pathway proteins such as PRAS40. idelalisib 0-10 AKT1 substrate 1 Homo sapiens 174-180 17923272-8 2007 CONCLUSIONS: Among many lifestyle factors, in addition to maintaining decreased BMI levels, moderate alcohol intake habits may have a significant, independent, and positive effect on adiponectin concentrations in the general population of Japanese females, similar to that of Caucasian populations. Alcohols 101-108 adiponectin, C1Q and collagen domain containing Homo sapiens 183-194 17593394-5 2007 We found strong evidence (P <or= 0.02) for interaction effects of polymorphisms from the bradykinin receptor (BDKRB2) gene and alcohol consumption on t-PA in females and males and on PAI-1 in males. Alcohols 130-137 plasminogen activator, tissue type Homo sapiens 153-157 17593394-9 2007 In conclusion, the genetic architecture of t-PA and PAI-1 is dependent on the environmental context such as body size and alcohol use. Alcohols 122-129 plasminogen activator, tissue type Homo sapiens 43-47 17702043-7 2007 Both TITF-1 mutation carriers presented with infancy-onset, nonprogressive chorea, which responded to alcohol intake. Alcohols 102-109 NK2 homeobox 1 Homo sapiens 5-11 17785713-3 2007 Fibrinogen levels increased with age and showed continuous, approximately linear relations with several risk markers and slightly curvilinear associations with log triglycerides, albumin, and tobacco and alcohol consumption. Alcohols 204-211 fibrinogen beta chain Homo sapiens 0-10 17681033-0 2007 Role of medium-chain triglycerides in the alcohol-mediated cytochrome P450 2E1 induction of mitochondria. Alcohols 42-49 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 59-78 17681033-1 2007 BACKGROUND: Chronic alcohol consumption is known to induce cytochrome P450 2E1 (CYP2E1) leading to lipid peroxidation, mitochondrial dysfunction and hepatotoxicity. Alcohols 20-27 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 59-78 17681033-1 2007 BACKGROUND: Chronic alcohol consumption is known to induce cytochrome P450 2E1 (CYP2E1) leading to lipid peroxidation, mitochondrial dysfunction and hepatotoxicity. Alcohols 20-27 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 80-86 17681033-7 2007 RESULTS: After 21 days, compared to the controls, the alcohol and both alcohol-MCT groups had a significant increase in mitochondrial CYP2E1 (p < 0.05 for both). Alcohols 54-61 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 134-140 17681033-7 2007 RESULTS: After 21 days, compared to the controls, the alcohol and both alcohol-MCT groups had a significant increase in mitochondrial CYP2E1 (p < 0.05 for both). Alcohols 71-78 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 134-140 17681033-9 2007 When MCT replaced all the fat, like in the alcohol-MCT 32% group, CYP2E1 was significantly reduced by 40% in mitochondria (p < 0.05) and 30% in microsomes (p < 0.01). Alcohols 43-50 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 66-72 17681033-14 2007 CONCLUSION: Mitochondria participate in the induction of CYP2E1 by alcohol and contribute to lipid peroxidation and GSH depletion. Alcohols 67-74 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 57-63 17916057-7 2007 Important work has elucidated the relationship between CYP2E1-mediated formation of the hepatotoxic metabolite of acetaminophen and alcohol consumption. Alcohols 132-139 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 55-61 17137657-1 2007 The association between alcohol consumption and CRP was evaluated in a longitudinal study among 72 middle aged adults for whom 572 repeated measurements of CRP were obtained. Alcohols 24-31 C-reactive protein Homo sapiens 48-51 17137657-4 2007 Average alcohol consumption during the last 12 months showed a clear U-shaped relationship with CRP-levels, with lowest levels found for moderate alcohol consumption of less than 16 g/day. Alcohols 8-15 C-reactive protein Homo sapiens 96-99 17137657-4 2007 Average alcohol consumption during the last 12 months showed a clear U-shaped relationship with CRP-levels, with lowest levels found for moderate alcohol consumption of less than 16 g/day. Alcohols 146-153 C-reactive protein Homo sapiens 96-99 17626977-0 2007 The acylation of lipophilic alcohols by lysosomal phospholipase A2. Alcohols 28-36 phospholipase A2 group XV Homo sapiens 40-66 17622585-0 2007 Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. Alcohols 26-33 insulin Homo sapiens 37-44 17622585-0 2007 Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. Alcohols 89-96 insulin Homo sapiens 37-44 17622585-6 2007 Thus, alcohol exerts biphasic actions on hepatic insulin signaling, such that low doses activate insulin signaling pathways associated with reduced p55gamma to increase nSREBP-1, whereas high doses of ethanol elevate TRB3 and suppress insulin signaling to decrease SREBP-1. Alcohols 6-13 insulin Homo sapiens 49-56 17622585-6 2007 Thus, alcohol exerts biphasic actions on hepatic insulin signaling, such that low doses activate insulin signaling pathways associated with reduced p55gamma to increase nSREBP-1, whereas high doses of ethanol elevate TRB3 and suppress insulin signaling to decrease SREBP-1. Alcohols 6-13 insulin Homo sapiens 97-104 17925471-8 2007 Compared with whites, Filipinas (beta = -5.06, p < 0.0001) and African-Americans (beta = -6.85, p < 0.0001) had significantly lower adiponectin levels after adjusting for age, waist-to-hip ratio, HOMA-IR, triglycerides, high-density lipoprotein (HDL) cholesterol, exercise, and alcohol use. Alcohols 284-291 adiponectin, C1Q and collagen domain containing Homo sapiens 138-149 17531960-0 2007 Regarding "Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system". Alcohols 33-40 prepronociceptin Homo sapiens 76-86 17651701-9 2007 Lower correlations with larger alcohol leaving group parabens are consistent with more hCE2 involvement. Alcohols 31-38 carboxylesterase 2 Homo sapiens 87-91 17572454-3 2007 A wealth of data indicates that neuropeptides, e.g., NPY, CRH, somatostatin, tachykinins and CGRP play a role in affective disorders and alcohol use/abuse. Alcohols 137-144 neuropeptide Y Rattus norvegicus 53-56 17572454-3 2007 A wealth of data indicates that neuropeptides, e.g., NPY, CRH, somatostatin, tachykinins and CGRP play a role in affective disorders and alcohol use/abuse. Alcohols 137-144 corticotropin releasing hormone Rattus norvegicus 58-61 17572454-3 2007 A wealth of data indicates that neuropeptides, e.g., NPY, CRH, somatostatin, tachykinins and CGRP play a role in affective disorders and alcohol use/abuse. Alcohols 137-144 somatostatin Rattus norvegicus 63-75 17610065-0 2007 Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis. Alcohols 70-77 TNF superfamily member 10 Homo sapiens 93-98 17610065-8 2007 As heat shock, these alcohols increased, in a D609-sensitive manner, membrane fluidity in the presence of TRAIL, the recognition of TRAIL death receptors, and ceramide levels. Alcohols 21-29 TNF superfamily member 10 Homo sapiens 106-111 17610065-8 2007 As heat shock, these alcohols increased, in a D609-sensitive manner, membrane fluidity in the presence of TRAIL, the recognition of TRAIL death receptors, and ceramide levels. Alcohols 21-29 TNF superfamily member 10 Homo sapiens 132-137 18063850-0 2007 Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue. Alcohols 10-17 resistin Rattus norvegicus 34-42 18063850-0 2007 Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue. Alcohols 10-17 resistin Rattus norvegicus 71-79 18063850-4 2007 Effect of long-time (28 days) ad libitum moderate alcohol (6% ethanol solution) intake on serum resistin and resistin mRNA level in adipose tissue of rats (A) was compared to control (C) and pair-fed (PF) animals. Alcohols 50-57 resistin Rattus norvegicus 96-104 18063850-7 2007 Alcohol intake significantly increased serum resistin and glucose, insulinemia remained unchanged. Alcohols 0-7 resistin Rattus norvegicus 45-53 18063850-10 2007 High resistin level as the consequence of long-time alcohol intake could contribute to smaller adipocytes, higher glycemia, attenuation of insulin-stimulated glucose transport in adipocytes. Alcohols 52-59 resistin Rattus norvegicus 5-13 17995665-4 2007 The preintake of these agents significantly attenuated subsequent alcohol-induced lipid oxidation, glutathione (GSH) depletion, and activity reduction of catalase and glutathione peroxidase (P < 0.05); also attenuated were the alcohol-induced elevation of c-reactive protein (CRP), interleukin-6 (IL-6), IL-10 and tumor necrosis factor (TNF)-alpha (P < 0.05). Alcohols 66-73 interleukin 6 Mus musculus 285-298 17995665-4 2007 The preintake of these agents significantly attenuated subsequent alcohol-induced lipid oxidation, glutathione (GSH) depletion, and activity reduction of catalase and glutathione peroxidase (P < 0.05); also attenuated were the alcohol-induced elevation of c-reactive protein (CRP), interleukin-6 (IL-6), IL-10 and tumor necrosis factor (TNF)-alpha (P < 0.05). Alcohols 66-73 interleukin 6 Mus musculus 300-304 17995665-4 2007 The preintake of these agents significantly attenuated subsequent alcohol-induced lipid oxidation, glutathione (GSH) depletion, and activity reduction of catalase and glutathione peroxidase (P < 0.05); also attenuated were the alcohol-induced elevation of c-reactive protein (CRP), interleukin-6 (IL-6), IL-10 and tumor necrosis factor (TNF)-alpha (P < 0.05). Alcohols 66-73 interleukin 10 Mus musculus 307-312 17995665-4 2007 The preintake of these agents significantly attenuated subsequent alcohol-induced lipid oxidation, glutathione (GSH) depletion, and activity reduction of catalase and glutathione peroxidase (P < 0.05); also attenuated were the alcohol-induced elevation of c-reactive protein (CRP), interleukin-6 (IL-6), IL-10 and tumor necrosis factor (TNF)-alpha (P < 0.05). Alcohols 66-73 tumor necrosis factor Mus musculus 317-350 17575268-0 2007 Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes. Alcohols 6-13 signal transducer and activator of transcription 3 Homo sapiens 24-29 17575268-0 2007 Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes. Alcohols 6-13 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 31-35 17575268-0 2007 Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes. Alcohols 6-13 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 86-89 17575268-3 2007 We identified that increased IL-10 production in human monocytes after acute in vivo alcohol consumption or in vitro alcohol treatment was associated with increased STAT3 activation. Alcohols 85-92 signal transducer and activator of transcription 3 Homo sapiens 165-170 17575268-3 2007 We identified that increased IL-10 production in human monocytes after acute in vivo alcohol consumption or in vitro alcohol treatment was associated with increased STAT3 activation. Alcohols 117-124 signal transducer and activator of transcription 3 Homo sapiens 165-170 17575268-4 2007 Alcohol alone induced and in combination with LPS augmented STAT3 phosphorylation at tyrosine 705 (tyr705) and serine 727 (ser727) residues and increased STAT3 binding to DNA. Alcohols 0-7 signal transducer and activator of transcription 3 Homo sapiens 60-65 17575268-4 2007 Alcohol alone induced and in combination with LPS augmented STAT3 phosphorylation at tyrosine 705 (tyr705) and serine 727 (ser727) residues and increased STAT3 binding to DNA. Alcohols 0-7 signal transducer and activator of transcription 3 Homo sapiens 154-159 17575268-5 2007 Upstream, alcohol activated the Src kinases, as indicated by an increase in phosphorylated and a decrease in nonphosphorylated Src proteins. Alcohols 10-17 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 32-35 17575268-5 2007 Upstream, alcohol activated the Src kinases, as indicated by an increase in phosphorylated and a decrease in nonphosphorylated Src proteins. Alcohols 10-17 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 127-130 17606256-4 2007 Feeding rats an alcohol-containing diet for 4 weeks elicited an increase in hepatic triglyceride content and induced CYP2E1. Alcohols 16-23 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 117-123 17889312-6 2007 Concentrations of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 in BALF in the alcohol consumption group were increased. Alcohols 100-107 tumor necrosis factor Homo sapiens 18-45 17889312-7 2007 Interferon (IFN)-gamma concentrations were lower in the alcohol consumption group at later times of infection. Alcohols 56-63 interferon gamma Homo sapiens 0-22 17889312-10 2007 IFN-alpha/beta was evident in BALF at low concentrations in the alcohol consumption group for several days after infection, and increased mRNA for IFN-alpha/beta was also evident in the alcohol consumption group. Alcohols 64-71 interferon alpha 1 Homo sapiens 0-9 17889312-10 2007 IFN-alpha/beta was evident in BALF at low concentrations in the alcohol consumption group for several days after infection, and increased mRNA for IFN-alpha/beta was also evident in the alcohol consumption group. Alcohols 186-193 interferon alpha 1 Homo sapiens 147-156 17889313-6 2007 We determined that chronic alcohol ingestion affected the expression of multiple claudins; most striking were decreases in claudin-1 and claudin-7, and an increase in claudin-5, in the whole lung and in alveolar epithelial monolayers derived from alcohol-fed rats. Alcohols 27-34 claudin 7 Rattus norvegicus 137-146 17889313-7 2007 In parallel, immunocytochemistry of alveolar epithelial monolayers from alcohol-fed rats revealed abnormal intracellular accumulation of claudin-7 protein and relatively decreased localization to cell membranes. Alcohols 72-79 claudin 7 Rattus norvegicus 137-146 17684217-1 2007 BACKGROUND: Whether alcohol intake is associated with concentrations of interleukin-6 (IL-6) and serum amyloid P (SAP) is uncertain. Alcohols 20-27 interleukin 6 Homo sapiens 72-85 17684217-1 2007 BACKGROUND: Whether alcohol intake is associated with concentrations of interleukin-6 (IL-6) and serum amyloid P (SAP) is uncertain. Alcohols 20-27 interleukin 6 Homo sapiens 87-91 17684217-6 2007 CONCLUSIONS: Among older adults free of clinical cardiovascular disease, specific IL-6 promoter and apo E alleles appeared to confer positive associations of alcohol consumption with IL-6 concentrations. Alcohols 158-165 interleukin 6 Homo sapiens 82-86 17684217-6 2007 CONCLUSIONS: Among older adults free of clinical cardiovascular disease, specific IL-6 promoter and apo E alleles appeared to confer positive associations of alcohol consumption with IL-6 concentrations. Alcohols 158-165 apolipoprotein E Homo sapiens 100-105 17684217-6 2007 CONCLUSIONS: Among older adults free of clinical cardiovascular disease, specific IL-6 promoter and apo E alleles appeared to confer positive associations of alcohol consumption with IL-6 concentrations. Alcohols 158-165 interleukin 6 Homo sapiens 183-187 17650292-8 2007 Logistic regression analysis identified type of infection (HCV vs HBV), alcohol consumption more than 25 g daily, serum total globulin and low C-peptide as significant predictive variables associated with high adiponectin levels. Alcohols 72-79 adiponectin, C1Q and collagen domain containing Homo sapiens 210-221 17592394-10 2007 DAPK was also correlated with current alcohol consumption (P < .028), but neither TIMP-3 nor DAPK hypermethylation was significantly correlated with other clinical variables or with survival. Alcohols 38-45 death associated protein kinase 1 Homo sapiens 0-4 17590496-5 2007 Osteoblast proliferation rate and TGF-beta1, IL-6 and TNFalpha syntheses were significantly affected by alcohol exposure. Alcohols 104-111 transforming growth factor, beta 1 Rattus norvegicus 34-43 17590496-5 2007 Osteoblast proliferation rate and TGF-beta1, IL-6 and TNFalpha syntheses were significantly affected by alcohol exposure. Alcohols 104-111 interleukin 6 Rattus norvegicus 45-49