PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27687218-5	2016	The oxysterols potentially most closely involved in the pathogenesis of AD are 24-hydroxycholesterol and 27-hydroxycholesterol, respectively deriving from cholesterol oxidation by the enzymes CYP46A1 and CYP27A1.	Oxysterols	4-14	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	192-199	
21576599-4	2011	This oxysterol is also synthesized by sterol 27-hydroxylase (CYP27A1) and cholesterol 24-hydroxylase(CYP46A1), but it is only a minor product of these enzymes.	Oxysterols	5-14	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	101-108	
15148325-10	2004	Oxysterols also inhibited protein kinase C activity and APP secretion following stimulation of protein kinase C. The selective expression of CYP46A1 around neuritic plaques and the potent inhibition of APP processing in neurons by 24(S)-hydroxycholesterol suggests that CYP46A1 affects the pathophysiology of AD and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease.	Oxysterols	0-10	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	141-148	
15148325-10	2004	Oxysterols also inhibited protein kinase C activity and APP secretion following stimulation of protein kinase C. The selective expression of CYP46A1 around neuritic plaques and the potent inhibition of APP processing in neurons by 24(S)-hydroxycholesterol suggests that CYP46A1 affects the pathophysiology of AD and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease.	Oxysterols	0-10	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	270-277	
15148325-10	2004	Oxysterols also inhibited protein kinase C activity and APP secretion following stimulation of protein kinase C. The selective expression of CYP46A1 around neuritic plaques and the potent inhibition of APP processing in neurons by 24(S)-hydroxycholesterol suggests that CYP46A1 affects the pathophysiology of AD and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease.	Oxysterols	0-10	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	270-277	
33192294-7	2020	Our results suggest that rodents show similarity to humans for studying the impact of CYP46A1 inhibitors and that rapid, local modulation of oxysterols can be achieved through CYP46A1 inhibition.	Oxysterols	141-151	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	176-183	
11514559-2	2001	These oxysterols are formed from cholesterol by specific cytochrome P450 enzymes, CYP27, CYP46, and CYP7A, respectively.	Oxysterols	6-16	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	89-94