PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26689473-4	2016	It remains to identify the link between ERK/Akt up-regulation and the consequent quenching effect on ROS intracellular level that efficiently and markedly delay the pro-apoptotic effect of the oxysterol.	Oxysterols	193-202	AKT serine/threonine kinase 1	Homo sapiens	44-47	
26689473-6	2016	The 27-OH-exerted induction of Nrf2 and subsequently of the target genes, HO-1 and NQO-1, was proved to be: (i) dependent upon the activation of ERK and Akt pathways, (ii) directly responsible for the quenching of intracellular oxidative stress and by this way (iii) ultimately responsible for the observed oxysterol-induced pro-survival response.	Oxysterols	307-316	AKT serine/threonine kinase 1	Homo sapiens	153-156	
22617754-6	2012	This new study, in combination with important prior work, provides clues to several long-standing mysteries, such as how AKT might regulate lipid-lowering and glucose-lowering pathways that become insulin-resistant but also lipogenic pathways that remain insulin-responsive, as well as a potential role for NOX4 in insulin-stimulated generation of oxysterol ligands for LXR, a key lipogenic factor.	Oxysterols	348-357	AKT serine/threonine kinase 1	Homo sapiens	121-124	
18495460-4	2009	This oxysterol also induces important changes in lipid content and/or organization of the cytoplasmic membrane demonstrated with merocyanine 540 and fluorescence anisotropy, a loss of PI3-K activity and dephosphorylation of PDK-1 and Akt.	Oxysterols	5-14	AKT serine/threonine kinase 1	Homo sapiens	234-237	
25110320-5	2014	In turn, stimulation of ERK and PI3K/Akt both significantly quenched ROS steady state and markedly phosphorylated Bad, thereby determining a marked delay of the oxysterol s proapoptotic action.	Oxysterols	161-170	AKT serine/threonine kinase 1	Homo sapiens	37-40	
18186953-8	2008	Akt activation was decreased in the oxysterol-treated cells compared with control cells; however, this did not attain significance.	Oxysterols	36-45	AKT serine/threonine kinase 1	Homo sapiens	0-3