PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32698250-3 2021 CYP27A1 and CYP46A1 are the major oxysterol-producing enzymes in the retina that convert cholesterol to 27- and 24-hydroxycholesterol, respectively. Oxysterols 34-43 cytochrome P450, family 27, subfamily a, polypeptide 1 Mus musculus 0-7 18068744-9 2008 Perhaps surprisingly, the retina expresses CYP 27A1 and CYP 46A1, enzymes with broad substrate specificity for ring-modified sterols, implying that, in addition to a rich blood supply for disposing of potentially toxic oxysterols, they can be detoxified locally. Oxysterols 219-229 cytochrome P450, family 27, subfamily a, polypeptide 1 Mus musculus 43-51 19373502-1 2009 Cholesterol metabolism as initiated by mitochondrial sterol 27-hydroxylase (CYP27A1) is a ubiquitous pathway capable of synthesizing multiple key regulatory oxysterols involved in lipid homeostasis. Oxysterols 157-167 cytochrome P450, family 27, subfamily a, polypeptide 1 Mus musculus 53-74 19373502-1 2009 Cholesterol metabolism as initiated by mitochondrial sterol 27-hydroxylase (CYP27A1) is a ubiquitous pathway capable of synthesizing multiple key regulatory oxysterols involved in lipid homeostasis. Oxysterols 157-167 cytochrome P450, family 27, subfamily a, polypeptide 1 Mus musculus 76-83 26082378-1 2015 Cytochrome P450 CYP27A1 is the only enzyme in humans converting cholesterol to 27-hydroxycholesterol, an oxysterol of multiple functions, including tissue-specific modulation of estrogen and liver X receptors. Oxysterols 105-114 cytochrome P450, family 27, subfamily a, polypeptide 1 Mus musculus 16-23 28928671-16 2017 In addition, the increase and reduction of Cyp27a1 and Cyp7b1 in trained mice may contribute to enhance levels of 27-OH C. Both oxysterols may act as an alternative pathway for the RCT contributing to the reduction of cholesterol in the aortic arch preventing atherogenesis. Oxysterols 128-138 cytochrome P450, family 27, subfamily a, polypeptide 1 Mus musculus 43-50