PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20395595-0 2010 Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. Oxysterols 74-83 ATP binding cassette subfamily G member 1 Homo sapiens 59-64 28869506-2 2017 It is now well established that ABCG1 promotes the export of lipids, including cholesterol, phospholipids, sphingomyelin and oxysterols, and plays a key role in the maintenance of tissue lipid homeostasis. Oxysterols 125-135 ATP binding cassette subfamily G member 1 Homo sapiens 32-37 22488423-5 2012 The ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, and the scavenger receptor B type 1 mediate multiple intracellular signaling pathways as well as the efflux of cholesterol and/or oxysterols in response to apoA-I/HDL. Oxysterols 191-201 ATP binding cassette subfamily G member 1 Homo sapiens 54-59 22488423-7 2012 SUMMARY: Current data suggest that in endothelial cells ABCA1 and ABCG1 mediate the activation of intracellular signaling pathways primarily through the efflux of cholesterol and oxysterols to apoA-I/HDL. Oxysterols 179-189 ATP binding cassette subfamily G member 1 Homo sapiens 66-71 22095132-8 2011 Mutagenesis studies identify critical residues in the TM domains that are important for ABCG1 to alter sterol efflux, induce sterol regulatory element binding protein-2 (SREBP-2) processing, and selectively attenuate the oxysterol-mediated repression of SREBP-2 processing. Oxysterols 221-230 ATP binding cassette subfamily G member 1 Homo sapiens 88-93 20570635-0 2010 Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. Oxysterols 88-97 ATP binding cassette subfamily G member 1 Homo sapiens 20-25 20570635-7 2010 Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity. Oxysterols 80-90 ATP binding cassette subfamily G member 1 Homo sapiens 39-44 20570635-7 2010 Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity. Oxysterols 80-89 ATP binding cassette subfamily G member 1 Homo sapiens 39-44 20570635-8 2010 These results identify syncytial ABCA1 and ABCG1 as important, inducible cholesterol transporters which also prevent placental accumulation of cytotoxic oxysterols. Oxysterols 153-163 ATP binding cassette subfamily G member 1 Homo sapiens 43-48 24320932-1 2013 ATP-binding cassette transporter G1 (ABCG1) mediates cholesterol and oxysterol efflux onto lipidated lipoproteins and plays an important role in macrophage reverse cholesterol transport. Oxysterols 69-78 ATP binding cassette subfamily G member 1 Homo sapiens 0-35 24320932-1 2013 ATP-binding cassette transporter G1 (ABCG1) mediates cholesterol and oxysterol efflux onto lipidated lipoproteins and plays an important role in macrophage reverse cholesterol transport. Oxysterols 69-78 ATP binding cassette subfamily G member 1 Homo sapiens 37-42 23298226-2 2013 Mitochondrial cholesterol transport is rate-limiting in the CYP27A1 (sterol 27-hydroxylase)-dependent generation of oxysterol ligands for LXR (liver X receptor) transcription factors that regulate the expression of genes encoding proteins in the cholesterol efflux pathway, such as ABC transporters (ATP-binding cassette transporters) ABCA1 and ABCG1. Oxysterols 116-125 ATP binding cassette subfamily G member 1 Homo sapiens 345-350 19895785-0 2009 ABCG1 mediated oxidized LDL-derived oxysterol efflux from macrophages. Oxysterols 36-45 ATP binding cassette subfamily G member 1 Homo sapiens 0-5 19895785-11 2009 CONCLUSIONS: ABCG1 mediates oxysterol efflux from oxLDL-loaded macrophages, and the exported oxysterol by ABCG1 pathway can be selectively taken up by hepatocytes. Oxysterols 28-37 ATP binding cassette subfamily G member 1 Homo sapiens 13-18 18271871-5 2008 ABCA1 stimulates cholesterol efflux to lipid-poor apolipoproteins, whilst ABCG1 promotes efflux of cholesterol and oxysterols to HDL. Oxysterols 115-125 ATP binding cassette subfamily G member 1 Homo sapiens 74-79 18997165-13 2009 Activation of LXR by either endogenous oxysterols or synthetic agonists induces the expression of many genes, including those encoding ATP-binding cassette (ABC) transporters ABCA1, ABCG1, ABCG5, and ABCG8. Oxysterols 39-49 ATP binding cassette subfamily G member 1 Homo sapiens 182-187 10799558-9 2000 Oxysterol-dependent induction of white/ABC8 mRNA was blocked by actinomycin D but not by cycloheximide treatment of cells. Oxysterols 0-9 ATP binding cassette subfamily G member 1 Homo sapiens 39-43 17846428-6 2007 In transfected 293 cells, efflux of 7-ketocholesterol and related oxysterols was completely dependent on expression of ABCG1 and the presence of HDL in media. Oxysterols 66-76 ATP binding cassette subfamily G member 1 Homo sapiens 119-124 17408620-5 2007 In the current study, we investigated whether ABC transporter family member G1 (ABCG1) may be involved in oxysterol transport, since its gene expression is highly responsive to oxysterol loading. Oxysterols 106-115 ATP binding cassette subfamily G member 1 Homo sapiens 80-85 17408620-5 2007 In the current study, we investigated whether ABC transporter family member G1 (ABCG1) may be involved in oxysterol transport, since its gene expression is highly responsive to oxysterol loading. Oxysterols 177-186 ATP binding cassette subfamily G member 1 Homo sapiens 80-85 16730733-3 2007 We here demonstrate that unsaturated fatty acids significantly suppress the stimulatory effects of oxysterols and retinoids on the expression of ABCG1 mRNA and protein and the activity of the wild-type human ABCG1 promoter as well as ABCA1. Oxysterols 99-109 ATP binding cassette subfamily G member 1 Homo sapiens 145-150 16730733-3 2007 We here demonstrate that unsaturated fatty acids significantly suppress the stimulatory effects of oxysterols and retinoids on the expression of ABCG1 mRNA and protein and the activity of the wild-type human ABCG1 promoter as well as ABCA1. Oxysterols 99-109 ATP binding cassette subfamily G member 1 Homo sapiens 208-213 11500512-4 2001 Northern analysis using exon-specific probes confirms that oxysterol treatment results in >10-fold induction of ABCG1 transcripts that are derived from either exons 8-23 or exons 5, 7, and 11-23. Oxysterols 59-68 ATP binding cassette subfamily G member 1 Homo sapiens 115-120 17846428-10 2007 These findings indicate a specific role for ABCG1 in promoting efflux of 7-ketocholesterol and related oxysterols from macrophages onto HDL and in protecting these cells from oxysterol-induced cytotoxicity. Oxysterols 103-112 ATP binding cassette subfamily G member 1 Homo sapiens 44-49