PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19157829-4	2010	Moreover, the carotenoid strongly prevented the increase of NOX-4, hsp70 and hsp90 expressions as well as the phosphorylation of the redox-sensitive p38, JNK and ERK1/2 induced by the oxysterol.	Oxysterols	184-193	mitogen-activated protein kinase 3	Homo sapiens	162-168	
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Oxysterols	31-40	mitogen-activated protein kinase 3	Homo sapiens	116-122	
18317936-5	2009	Fluo-3 staining used in flow cytometry and video microscopy revealed an oxysterol-induced Ca(2+) influx, varying according to the oxysterol studied, leading to the activation of the MEK/ERK1/2 pathway as demonstrated by Western blot analysis.	Oxysterols	72-81	mitogen-activated protein kinase 3	Homo sapiens	186-192	
18317936-5	2009	Fluo-3 staining used in flow cytometry and video microscopy revealed an oxysterol-induced Ca(2+) influx, varying according to the oxysterol studied, leading to the activation of the MEK/ERK1/2 pathway as demonstrated by Western blot analysis.	Oxysterols	130-139	mitogen-activated protein kinase 3	Homo sapiens	186-192	
14992685-10	2004	The oxysterol also inhibited (i) the histamine- and thapsigargin-induced arachidonic acid release, and (ii) the phosphorylation of both cPLA2 and ERK1/2 (extracellular-signal-regulated kinases 1/2).	Oxysterols	4-13	mitogen-activated protein kinase 3	Homo sapiens	146-152	
16604541-8	2006	RESULTS: All oxysterols investigated are potent in vitro inducers of MCP-1, MIP-1beta, TNF-alpha, and/or IL-8 secretion, the latter involving the MEK/ERK1/2 cell signaling pathway.	Oxysterols	13-23	mitogen-activated protein kinase 3	Homo sapiens	150-156	
16214031-5	2005	Up-regulated expression and synthesis of MCP-1 by the oxysterol mixture was clearly dependent on a net increment of phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor kappaB (NF-kappaB) nuclear binding.	Oxysterols	54-63	mitogen-activated protein kinase 3	Homo sapiens	178-184