PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21395540-3	2011	These metabolites (oxysterols, bile acids, vitamin D3) act as activators of a battery of nuclear receptors, in particular liver X receptor (LXR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR) and vitamin D receptor (VDR).	Oxysterols	19-29	nuclear receptor subfamily 1 group H member 4	Homo sapiens	235-238	
31379749-4	2019	Oxysterol concentrations, the expression of key regulators liver X receptors (LXR), farnesoid X receptor (FXR), and oxysterol-binding proteins (OSBP) family are modulated in tumors and plasma of cancer patients, exposing these proteins and selected oxysterols as new potential biomarkers and drug targets.	Oxysterols	0-9	nuclear receptor subfamily 1 group H member 4	Homo sapiens	106-109	
12704471-1	2003	The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol catabolism to bile acids and feedback repression of bile acid synthesis, respectively.	Oxysterols	102-111	nuclear receptor subfamily 1 group H member 4	Homo sapiens	146-149	
16371446-7	2006	In contrast to our hypothesis, the oxysterol-induced up-regulation of BSEP is mediated through FXR but not LXR.	Oxysterols	35-44	nuclear receptor subfamily 1 group H member 4	Homo sapiens	95-98	
16371446-9	2006	Mutation of the FXR element IR1 in the BSEP promoter significantly reduced its ability to respond to oxysterol induction.	Oxysterols	101-110	nuclear receptor subfamily 1 group H member 4	Homo sapiens	16-19	
10462436-4	1999	Two other nuclear receptors, designated LXR and FXR, which are respectively activated by oxysterols and bile acids, also play a role in liver P450 expression, in this case regulation of P450 cholesterol 7alpha-hydroxylase, a key enzyme of bile acid biosynthesis.	Oxysterols	89-99	nuclear receptor subfamily 1 group H member 4	Homo sapiens	48-51