PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35464321-5	2022	27-hydroxycholesterol (27-OHC) is the major peripheral oxysterol that flows into the brain, and it affects beta-amyloid (Abeta) production and elimination as well as influencing other pathogenic mechanisms of AD.	Oxysterols	55-64	amyloid beta precursor protein	Homo sapiens	121-126	
33118626-5	2021	The second part concentrates in the effects of 24S-HC at the cellular level, describing how this oxysterol affects cell viability, amyloid beta production, neurotransmission, and transcriptional activity.	Oxysterols	97-106	amyloid beta precursor protein	Homo sapiens	131-143	
20836858-12	2010	The deleterious effects of this oxysterol ranged from Abeta accumulation to oxidative cell damage.	Oxysterols	32-41	amyloid beta precursor protein	Homo sapiens	54-59	
24612036-3	2014	The challenge of differentiated SK-N-BE human neuroblastoma cells with patho-physiologically relevant amounts of 27-OH and 24-OH showed that both oxysterols induce a net synthesis of Abeta1-42 by up-regulating expression levels of amyloid precursor protein and beta-secretase, as well as the beta-secretase activity.	Oxysterols	146-156	amyloid beta precursor protein	Homo sapiens	231-256	
24612036-5	2014	The reported findings link an impaired cholesterol oxidative metabolism to an excessive beta-amyloidogenesis and point to NAC as an efficient inhibitor of oxysterols-induced Abeta toxic peptide accumulation in the brain.	Oxysterols	155-165	amyloid beta precursor protein	Homo sapiens	174-179	
23800382-0	2013	The effect of oxysterols on the interaction of Alzheimer"s amyloid beta with model membranes.	Oxysterols	14-24	amyloid beta precursor protein	Homo sapiens	59-71	
23800382-2	2013	However, the effect of cholesterol and its oxidized derivatives, oxysterols, on Abeta-induced neurotoxicity to membranes is not fully understood.	Oxysterols	65-75	amyloid beta precursor protein	Homo sapiens	80-85	
23800382-4	2013	Our results have indicated that oxysterols rendered membranes more sensitive to Abeta, in contrast to role of cholesterol in inhibiting Abeta/membrane interaction.	Oxysterols	32-42	amyloid beta precursor protein	Homo sapiens	80-85	
23800382-8	2013	These findings suggest the enhancing effect of oxysterols on interaction of Abeta with membranes and contribute to clarify the harmful impact of cholesterol on Abeta-induced neurotoxicity by means of its oxidation.	Oxysterols	47-57	amyloid beta precursor protein	Homo sapiens	76-81	
18390616-9	2008	We attribute these effects to the reduction in intermolecular cohesive interactions caused by the presence of the second dipole of oxysterols, which reduces the energetic barrier for Abeta insertion into the bilayer.	Oxysterols	131-141	amyloid beta precursor protein	Homo sapiens	183-188	
15148325-7	2004	Both oxysterols inhibited production of Abeta in neurons, but 24(S)-hydroxycholesterol was approximately 1000-fold more potent than 27-hydroxycholesterol.	Oxysterols	5-15	amyloid beta precursor protein	Homo sapiens	40-45