PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20109441-4 2010 We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). methanethiosulfonate 31-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 20109441-4 2010 We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). methanethiosulfonate 31-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 20109441-4 2010 We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). methanethiosulfonate 31-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 19714254-8 2009 Herein, we report that, under conditions that spare the human AChE, a methanethiosulfonate-containing molecule at 6 microM irreversibly inhibited 95% of the AChE activity extracted from An. methanethiosulfonate 70-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 19714254-8 2009 Herein, we report that, under conditions that spare the human AChE, a methanethiosulfonate-containing molecule at 6 microM irreversibly inhibited 95% of the AChE activity extracted from An. methanethiosulfonate 70-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 19714254-11 2009 This type of inhibition is fast ( approximately 30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol. methanethiosulfonate 186-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 19714254-11 2009 This type of inhibition is fast ( approximately 30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol. methanethiosulfonate 186-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 19194505-6 2009 Herein we report the development of a methanethiosulfonate-containing small molecule that, at 6.0 microM, irreversibly inhibits 99% of all AChE activity extracted from the greenbug aphid (Schizaphis graminum) without any measurable inhibition of the human AChE. methanethiosulfonate 38-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 19194505-6 2009 Herein we report the development of a methanethiosulfonate-containing small molecule that, at 6.0 microM, irreversibly inhibits 99% of all AChE activity extracted from the greenbug aphid (Schizaphis graminum) without any measurable inhibition of the human AChE. methanethiosulfonate 38-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260