PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35405252-18 2022 Moreover, acacetin and apigenin, two components of Cortex Lycii, reduced the protein level of p-AKT and p-mTOR, and the reduction was also inhibited by Terazosin. acacetin 10-18 AKT serine/threonine kinase 1 Homo sapiens 96-99 34886812-0 2021 Amelioration of human peritoneal mesothelial cell co-culture-evoked malignant potential of ovarian cancer cells by acacetin involves LPA release-activated RAGE-PI3K/AKT signaling. acacetin 115-123 AKT serine/threonine kinase 1 Homo sapiens 165-168 34886812-13 2021 Mechanically, acacetin decreased lysophosphatidic acid (LPA) release from mesothelial cells, and subsequent activation of receptor for advanced glycation end-products (RAGE)-PI3K/AKT signaling in ovarian cancer cells. acacetin 14-22 AKT serine/threonine kinase 1 Homo sapiens 179-182 34886812-15 2021 CONCLUSIONS: Acacetin may not only engender direct inhibition of ovarian cancer cell malignancy, but also antagonize mesothelial cell-evoked malignancy by blocking LPA release-activated RAGE-PI3K/AKT signaling. acacetin 13-21 AKT serine/threonine kinase 1 Homo sapiens 196-199 35000605-0 2022 Acacetin inhibits invasion, migration and TGF-beta1-induced EMT of gastric cancer cells through the PI3K/Akt/Snail pathway. acacetin 0-8 AKT serine/threonine kinase 1 Homo sapiens 105-108 35000605-10 2022 In addition, acacetin suppressed the activation of PI3K/Akt signalling and decreased the phosphorylation levels of TGF-beta1-treated GC cells. acacetin 13-21 AKT serine/threonine kinase 1 Homo sapiens 56-59 35000605-13 2022 CONCLUSION: Our study showed that the invasion, metastasis and TGF-beta1-induced EMT of GC are inhibited by acacetin, and the mechanism may involve the suppression of the PI3K/Akt/Snail signalling pathway. acacetin 108-116 AKT serine/threonine kinase 1 Homo sapiens 176-179 29676234-0 2018 Low Dose of Acacetin Promotes Breast Cancer MCF-7 Cells Proliferation Through the Activation of ERK/ PI3K /AKT and Cyclin Signaling Pathway. acacetin 12-20 AKT serine/threonine kinase 1 Homo sapiens 107-110 32746771-7 2021 This study mainly represents that Galuteolin and Linarin in the Akt pathway can be perceived for OSCC treatment and other five CYP inhibitors - Diosmetin, Acacetin, Epicatechin, Eriodictyol and Capillin for the treatment of other diseases and cancers caused by overexpression of MAOB. acacetin 155-163 AKT serine/threonine kinase 1 Homo sapiens 64-67 29676234-10 2018 Moreover, the expressions of cell cycle-related molecules, ERK1/2 and PI3K/AKT were increased after treatment with acacetin, while the increases were effectively reversed by ER antagonist ICI 182,780. acacetin 115-123 AKT serine/threonine kinase 1 Homo sapiens 75-78 29676234-12 2018 CONCLUSION: Low dose of acacetin from 10-3 microM to microM promoted the proliferation of MCF-7 cells through the ERK/PI3K/AKT pathway and its downstream cyclin signaling. acacetin 24-32 AKT serine/threonine kinase 1 Homo sapiens 123-126 27817185-6 2017 Together, these results demonstrate that acacetin induces not only apoptotic cell death via activation of Bak, loss of Deltapsi, and activation of the mitochondrial caspase cascade, but also cytoprotective autophagy resulting from suppression of the Akt-mTOR pathway. acacetin 41-49 AKT serine/threonine kinase 1 Homo sapiens 250-253 29089232-5 2017 Acacetin also markedly acted on key molecules in apoptotic cell death pathways and reduced phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinases (PI3K)/Akt, and glycogen synthase kinase-3beta (GSK-3beta). acacetin 0-8 AKT serine/threonine kinase 1 Homo sapiens 224-227 28336971-4 2017 A natural flavonoid acacetin is then identified to be capable of modulating RARgamma-dependent AKT-p53 network. acacetin 20-28 AKT serine/threonine kinase 1 Homo sapiens 95-98 28336971-7 2017 Acacetin induces cancer cell apoptosis through antagonizing the non-genomic effect of RARgamma on AKT and p53. acacetin 0-8 AKT serine/threonine kinase 1 Homo sapiens 98-101 28336971-8 2017 When bound to RARgamma, acacetin prevents RARgamma from its activation of AKT followed by recovery of the normal p53 signaling. acacetin 24-32 AKT serine/threonine kinase 1 Homo sapiens 74-77 21893035-0 2011 Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1alpha pathway. acacetin 0-8 AKT serine/threonine kinase 1 Homo sapiens 73-76 21893035-4 2011 To further determine the potential mechanism of acacetin in inhibiting VEGF expression, we showed that acacetin inhibited HIF-1alpha expression and AKT activation. acacetin 103-111 AKT serine/threonine kinase 1 Homo sapiens 148-151 21893035-5 2011 Over-expression of HIF-1alpha or AKT restored acacetin-decreasing VEGF transcriptional activation, indicating that AKT and HIF-1 are the essential downstream targets of acacetin for inhibiting VEGF expression in the cells. acacetin 46-54 AKT serine/threonine kinase 1 Homo sapiens 33-36 21893035-5 2011 Over-expression of HIF-1alpha or AKT restored acacetin-decreasing VEGF transcriptional activation, indicating that AKT and HIF-1 are the essential downstream targets of acacetin for inhibiting VEGF expression in the cells. acacetin 46-54 AKT serine/threonine kinase 1 Homo sapiens 115-118 21893035-5 2011 Over-expression of HIF-1alpha or AKT restored acacetin-decreasing VEGF transcriptional activation, indicating that AKT and HIF-1 are the essential downstream targets of acacetin for inhibiting VEGF expression in the cells. acacetin 169-177 AKT serine/threonine kinase 1 Homo sapiens 33-36 21893035-5 2011 Over-expression of HIF-1alpha or AKT restored acacetin-decreasing VEGF transcriptional activation, indicating that AKT and HIF-1 are the essential downstream targets of acacetin for inhibiting VEGF expression in the cells. acacetin 169-177 AKT serine/threonine kinase 1 Homo sapiens 115-118 24285354-0 2014 Acacetin (5,7-dihydroxy-4"-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-kappaB/Akt signaling in prostate cancer cells. acacetin 0-8 AKT serine/threonine kinase 1 Homo sapiens 130-133 24285354-0 2014 Acacetin (5,7-dihydroxy-4"-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-kappaB/Akt signaling in prostate cancer cells. acacetin 10-41 AKT serine/threonine kinase 1 Homo sapiens 130-133 24285354-7 2014 Western blot anlaysis of various markers of signaling pathways revealed that acacetin targets the Akt and nuclear factor (NF)-kappaB signaling pathways by inhibiting the phosphorylation of IkappaBalpha and NF-kappaB in a dose-dependent manner. acacetin 77-85 AKT serine/threonine kinase 1 Homo sapiens 98-101 24285354-8 2014 Consistent with its ability to induce apoptosis, the acacetin-mediated inhibition of the pro-survival pathway, Akt, and of the NF-kappaB pathway was accompanied by a marked reduction in the levels of the NF-kappaB-regulated anti-apoptotic proteins, Bcl-2 and X-linked inhibitor of apoptosis protein (XIAP), as well as of the proliferative protein, cyclooxygenase (COX)-2. acacetin 53-61 AKT serine/threonine kinase 1 Homo sapiens 111-114 24285354-11 2014 Our findings suggest that acacetin exerts antitumor effects by targeting the Akt/NF-kappaB signaling pathway. acacetin 26-34 AKT serine/threonine kinase 1 Homo sapiens 77-80