PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32918384-4	2020	Doxorubicin decreased cell viability and increased ROS production in rat cardiomyoblasts; these effects are significantly countered by acacetin (0.3-3 muM) in a concentration-dependent manner via activating Sirt1/pAMPK signals and enhancing antioxidation (Nrf2/HO-1 and SOD1/SOD2) and anti-apoptosis.	acacetin	135-143	NFE2 like bZIP transcription factor 2	Rattus norvegicus	256-260	
33204066-14	2020	Acacetin exerted its effect by activating the Nrf2 pathway and inhibiting p38, JNK and ERK1/2 phosphorylation.	acacetin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	46-50	
32918384-0	2020	Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1-mediated activation of AMPK/Nrf2 signal molecules.	acacetin	45-53	NFE2 like bZIP transcription factor 2	Rattus norvegicus	92-96	
32918384-6	2020	The results demonstrate for the first time that doxorubicin cardiotoxicity is antagonized by acacetin via Sirt1-mediated activation of AMPK/Nrf2 signal molecules, indicating that acacetin may be a drug candidate used clinically for protecting against doxorubicin cardiomyopathy.	acacetin	93-101	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144	
32918384-6	2020	The results demonstrate for the first time that doxorubicin cardiotoxicity is antagonized by acacetin via Sirt1-mediated activation of AMPK/Nrf2 signal molecules, indicating that acacetin may be a drug candidate used clinically for protecting against doxorubicin cardiomyopathy.	acacetin	179-187	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144	
29867499-0	2018	The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway.	acacetin	20-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	131-135	
29867499-4	2018	Moreover, acacetin increased Nrf2 and HO-1 in a concentration-dependent manner, and rescued SOD1 and SOD2 reduction induced by hypoxia/reoxygenation insult.	acacetin	10-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	29-33	
29867499-5	2018	These beneficial effects of acacetin disappeared in cells with silenced Nrf2, suggesting that Nrf2 activation participates in the cardioprotective effect of acacetin against hypoxia/reoxygenation insult.	acacetin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	72-76	
29867499-5	2018	These beneficial effects of acacetin disappeared in cells with silenced Nrf2, suggesting that Nrf2 activation participates in the cardioprotective effect of acacetin against hypoxia/reoxygenation insult.	acacetin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-98	
29867499-5	2018	These beneficial effects of acacetin disappeared in cells with silenced Nrf2, suggesting that Nrf2 activation participates in the cardioprotective effect of acacetin against hypoxia/reoxygenation insult.	acacetin	157-165	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-98	
29867499-7	2018	Our results demonstrate for the first time that AMPK-mediated Nrf2 activation is involved in the cardiomyocytes protection of acacetin against hypoxia/reoxygenation injury by activating a series of intracellular signals involved in anti-oxidation, anti-inflammation, and anti-apoptosis.	acacetin	126-134	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-66