PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22519963-1 2012 GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases. long-chain fatty acids 36-58 insulin Homo sapiens 96-103 17445541-2 2007 The carnitine palmitoyltransferase (CPT) enzyme system facilitates the transport of long-chain fatty acids into mitochondria, and the gene for the hepatic isoform of CPT1 (CPT1A) is a candidate gene for metabolic disorders such as insulin resistance associated with fatty liver. long-chain fatty acids 84-106 insulin Homo sapiens 231-238 18281277-1 2008 Here we report that in skeletal muscle cells the contribution to insulin resistance and inflammation of two common dietary long-chain fatty acids depends on the channeling of these lipids to distinct cellular metabolic fates. long-chain fatty acids 123-145 insulin Homo sapiens 65-72 17620421-11 2007 Ceramides or their metabolites could contribute to adverse effects of long-chain fatty acids on insulin resistance and inflammation. long-chain fatty acids 70-92 insulin Homo sapiens 96-103 17052194-6 2006 GPR40, activated by medium and long-chain fatty acids, has been shown to potentiate insulin secretion at the beta-cell, and has been hypothesized to participate in the detrimental effects of chronic fatty acid exposure on beta-cell function. long-chain fatty acids 31-53 insulin Homo sapiens 84-91 17130495-1 2006 The secretagogue, the incretin-like, and the suppressive activities of long-chain fatty acids (LCFAs) in modulating insulin secretion in vivo and in cultured islets were simulated here by beta,beta"-tetramethyl-hexadecanedioic acid (M16) and alpha,alpha"-tetrachloro-tetradecanedioic acid (Cl-DICA). long-chain fatty acids 71-93 insulin Homo sapiens 116-123 15127202-1 2004 AIMS/HYPOTHESIS: Defective oxidation of long-chain fatty acids is a feature of insulin resistance and Type 2 diabetes. long-chain fatty acids 40-62 insulin Homo sapiens 79-86 16611988-1 2006 Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues. long-chain fatty acids 115-137 insulin Homo sapiens 174-181 15929861-1 2005 Acute increases in plasma levels of long-chain fatty acids raise plasma insulin levels by stimulating insulin secretion or by decreasing insulin clearance. long-chain fatty acids 36-58 insulin Homo sapiens 72-79 15929861-1 2005 Acute increases in plasma levels of long-chain fatty acids raise plasma insulin levels by stimulating insulin secretion or by decreasing insulin clearance. long-chain fatty acids 36-58 insulin Homo sapiens 102-109 35624726-1 2022 The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. long-chain fatty acids 74-96 insulin Homo sapiens 151-158 9342538-8 1997 Insulin and glucocorticoids increase leptin expression, whereas catecholamines, via beta-adrenergic receptors and cAMP, and long-chain fatty acids (and thiazolidinediones), via PPARy, inhibit leptin expression. long-chain fatty acids 124-146 insulin Homo sapiens 0-7 35001637-7 2022 Many kinds of natural products promote white adipose tissue browning, such as alkaloids, flavonoids, terpenoids, and long-chain fatty acids, which can also ameliorate metabolic disorders including obesity, insulin resistance and diabetes. long-chain fatty acids 117-139 insulin Homo sapiens 206-213 30785686-6 2018 In the later stages of phylogenesis, insulin initiated: a) the transformation of carnivorous ancestors of the species Homo sapiens in the ocean into a herbivorous species while living on land; b) the formation of the new biological function of locomotion and c) the dominance of the oleic variant of the metabolism of long-chain fatty acids with higher kinetic parameters of mitochondria oxidation. long-chain fatty acids 318-340 insulin Homo sapiens 37-44 6367855-1 1983 Stimulation of lipid synthesis by insulin in MCF-7 human breast cancer cells is characterized by an increase in acetate incorporation into long-chain fatty acids. long-chain fatty acids 139-161 insulin Homo sapiens 34-41 29277329-2 2018 Evidence indicates that this increased risk is linked to an altered cardiac substrate preference of the insulin resistant heart, which shifts from a balanced utilization of glucose and long-chain fatty acids (FAs) towards an almost complete reliance on FAs as main fuel source. long-chain fatty acids 185-207 insulin Homo sapiens 104-111 28955759-1 2017 Adipocyte fatty acid-binding protein (AFABP: FABP4) is a member of the intracellular lipid-binding protein family that is thought to target long-chain fatty acids to nuclear receptors such as peroxisome proliferator-activated receptor gamma (PPARgamma), which in turn plays roles in insulin resistance and obesity. long-chain fatty acids 140-162 insulin Homo sapiens 283-290 27807695-1 2017 The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders. long-chain fatty acids 114-136 insulin Homo sapiens 206-213 27807695-1 2017 The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders. long-chain fatty acids 114-136 insulin Homo sapiens 236-243 27117849-2 2016 Medium-chain fatty acids (MCFAs) have anti-obesogenic effects in rodents and humans, while long-chain fatty acids (LCFAs) cause increases in body weight and insulin resistance. long-chain fatty acids 91-113 insulin Homo sapiens 157-164 25946120-7 2015 At 4 days after surgery, insulin levels correlated positively with metabolites of branched chain and aromatic amino acid metabolism and negatively with triglycerides with long-chain fatty acids. long-chain fatty acids 171-193 insulin Homo sapiens 25-32 24005625-2 2013 Insulin release is chiefly stimulated by glucose, but also modulated by other nutrients, including long-chain fatty acids which potentiate glucose-induced insulin secretion. long-chain fatty acids 99-121 insulin Homo sapiens 0-7 23903678-1 2013 Recent animal studies have indicated that overexpression of the elongation of long-chain fatty acids family member 6 (Elovl6) gene can cause insulin resistance and beta-cell dysfunction. long-chain fatty acids 78-100 insulin Homo sapiens 141-148