PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33488300-9	2021	The content of TNF-alpha was significantly increased, and the contents of VEGF and TGF-beta1 were decreased in SGC-7901 cells incubated with z-guggulsterone.	pregna-4,17-diene-3,16-dione	141-156	tumor necrosis factor	Homo sapiens	15-24	
20971513-4	2010	METHODS: The effect of guggulsterone on LPS-induced tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) expression was evaluated in HMEEC by real-time reverse transcription polymerase chain reaction (RT-PCR).	pregna-4,17-diene-3,16-dione	23-36	tumor necrosis factor	Homo sapiens	81-90	
20971513-6	2010	RESULTS: Guggulsterone significantly inhibited LPS-induced upregulation of TNF-alpha and COX-2 in a dose-dependent manner.	pregna-4,17-diene-3,16-dione	9-22	tumor necrosis factor	Homo sapiens	75-84	
20971513-9	2010	CONCLUSIONS: These results show that the guggulsterone has inhibitory effect on TNF-alpha expression and COX-2 production and it may be mediated through its inhibition of nuclear factor-kB activation.	pregna-4,17-diene-3,16-dione	41-54	tumor necrosis factor	Homo sapiens	80-89	
30844798-12	2019	CDCA increased IL-6, tumor necrosis factor-alpha (TNF-alpha), and vascular endothelial growth factor release, whereas guggulsterone significantly blocked IL-6 and TNF-alpha release.	pregna-4,17-diene-3,16-dione	118-131	tumor necrosis factor	Homo sapiens	163-172