PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26879835-6	2016	Results showed that Z-guggulsterone reduced inducible nitric oxide (iNOS) protein expression as well as nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production in LPS-stimulated BV-2 cells.	pregna-4,17-diene-3,16-dione	20-35	tumor necrosis factor	Mus musculus	123-150	
26879835-6	2016	Results showed that Z-guggulsterone reduced inducible nitric oxide (iNOS) protein expression as well as nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production in LPS-stimulated BV-2 cells.	pregna-4,17-diene-3,16-dione	20-35	tumor necrosis factor	Mus musculus	152-161	
26879835-7	2016	Z-guggulsterone also reduced the mRNA level of iNOS, TNF-alpha, and IL-6.	pregna-4,17-diene-3,16-dione	0-15	tumor necrosis factor	Mus musculus	53-62	
20195240-4	2010	Two guggulsterone derivatives, GG-50B and GG-52, significantly inhibited the activated NF-kappaB signals and the upregulated expression of interleukin-8 (IL-8) in COLO 205 cells stimulated with tumor necrosis factor-alpha (TNF-alpha).	pregna-4,17-diene-3,16-dione	4-17	tumor necrosis factor	Mus musculus	223-232	
18953480-3	2009	METHODS AND RESULTS: Guggulsterone inhibited TNF-alpha-induced endothelial TF protein expression and surface activity in a concentration-dependent manner; in contrast, dexamethasone did not affect TNF-alpha-induced TF expression.	pregna-4,17-diene-3,16-dione	21-34	tumor necrosis factor	Mus musculus	45-54	
18953480-5	2009	Real-time polymerase chain reaction revealed that guggulsterone inhibited TNF-alpha-induced TF mRNA expression; moreover, it impaired activation of the MAP kinases JNK and p38, while that of ERK remained unaffected.	pregna-4,17-diene-3,16-dione	50-63	tumor necrosis factor	Mus musculus	74-83