PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17475222-5 2007 Guggulsterone suppressed the proliferation of cells through inhibition of DNA synthesis, producing cell cycle arrest in S-phase, and this arrest correlated with a decrease in the levels of cyclin D1 and cdc2 and a concomitant increase in the levels of cyclin-dependent kinase inhibitor p21 and p27. pregna-4,17-diene-3,16-dione 0-13 cyclin D1 Homo sapiens 189-198 21118500-11 2010 In addition, GS treatment significantly reduced the expression of anti-apoptotic proteins, Bcl-2, xIAP, Mcl1, survivin, cyclin D1 and c-myc, thus committing cells to apoptosis. pregna-4,17-diene-3,16-dione 13-15 cyclin D1 Homo sapiens 120-129