PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17475222-7	2007	The apoptosis induced by guggulsterone was also indicated by the activation of caspase-8, bid cleavage, cytochrome c release, caspase-9 activation, caspase-3 activation, and PARP cleavage.	pregna-4,17-diene-3,16-dione	25-38	cytochrome c, somatic	Homo sapiens	104-116	
31581454-6	2019	Our study evidenced that GS treatment altered expression of Bcl-2 mediated the mitochondrial release of cytochrome c which triggered the formation of apoptosome as well as activation of caspase-3/7 leading to death of HCT 116 cells via intrinsic apoptosis pathway.	pregna-4,17-diene-3,16-dione	25-27	cytochrome c, somatic	Homo sapiens	104-116	
21118500-10	2010	These events initiate the intrinsic mitochondrial pathway of apoptosis, as revealed by increased levels of cytochrome c in cytoplasmic extracts of GS-treated SCC4 cells.	pregna-4,17-diene-3,16-dione	147-149	cytochrome c, somatic	Homo sapiens	107-119