PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29368696-7	2018	Guggulsterone microsphere incorporated aggregates exhibited the highest levels of TUJ1 expression as well as high Olig 2 expression, an inhibitor of the STAT3 astrogenesis pathway previously known as a target for guggulsterone in cancer treatment.	pregna-4,17-diene-3,16-dione	0-13	signal transducer and activator of transcription 3	Homo sapiens	153-158	
30181308-0	2018	Editor"s Note: Guggulsterone, a Farnesoid X Receptor Antagonist, Inhibits Constitutive and Inducible STAT3 Activation through Induction of a Protein Tyrosine Phosphatase SHP-1.	pregna-4,17-diene-3,16-dione	15-28	signal transducer and activator of transcription 3	Homo sapiens	101-106	
29368696-7	2018	Guggulsterone microsphere incorporated aggregates exhibited the highest levels of TUJ1 expression as well as high Olig 2 expression, an inhibitor of the STAT3 astrogenesis pathway previously known as a target for guggulsterone in cancer treatment.	pregna-4,17-diene-3,16-dione	213-226	signal transducer and activator of transcription 3	Homo sapiens	153-158	
19762335-3	2009	Guggulsterone induced decreased expression of both phosphotyrosine and total signal transducer and activator of transcription (STAT)-3, which contributed to guggulsterone"s growth inhibitory effect.	pregna-4,17-diene-3,16-dione	157-170	signal transducer and activator of transcription 3	Homo sapiens	77-134	
21903093-1	2011	Guggulsterone (GGS) has anti-tumor and anti-angiogenesis potential by suppressing nuclear factor-kappaB and STAT3 activity.	pregna-4,17-diene-3,16-dione	0-13	signal transducer and activator of transcription 3	Homo sapiens	108-113	
19762335-0	2009	Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3.	pregna-4,17-diene-3,16-dione	0-13	signal transducer and activator of transcription 3	Homo sapiens	72-122	
19762335-3	2009	Guggulsterone induced decreased expression of both phosphotyrosine and total signal transducer and activator of transcription (STAT)-3, which contributed to guggulsterone"s growth inhibitory effect.	pregna-4,17-diene-3,16-dione	0-13	signal transducer and activator of transcription 3	Homo sapiens	77-134	
19762335-5	2009	In a xenograft model of HNSCC, guggulsterone treatment resulted in increased apoptosis and decreased expression of STAT3.	pregna-4,17-diene-3,16-dione	31-44	signal transducer and activator of transcription 3	Homo sapiens	115-120	
19762335-7	2009	Our results suggest that guggulsterone-mediated inhibition of STAT3 and HIF-1alpha provide a biologic rationale for further clinical investigation of this compound in the treatment of HNSCC.	pregna-4,17-diene-3,16-dione	25-38	signal transducer and activator of transcription 3	Homo sapiens	62-67	
19020709-9	2008	The recruitment of STAT3 and ARNT, but not HIF-1alpha, to the VEGF promoter was inhibited by guggulsterone treatment.	pregna-4,17-diene-3,16-dione	93-106	signal transducer and activator of transcription 3	Homo sapiens	19-24	
19020709-0	2008	Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells.	pregna-4,17-diene-3,16-dione	0-13	signal transducer and activator of transcription 3	Homo sapiens	48-53	
19020709-5	2008	Using chromatin immunoprecipitation assay, we tested whether guggulsterone affects the recruitment of STAT3, ARNT and HIF-1alpha to the human VEGF promoter.	pregna-4,17-diene-3,16-dione	61-74	signal transducer and activator of transcription 3	Homo sapiens	102-107	
19020709-8	2008	Guggulsterone significantly reduced cell viability in colon cancer cells in a dose-dependent manner and blocked VEGF, ARNT and STAT3 expression prominently in hypoxic conditions.	pregna-4,17-diene-3,16-dione	0-13	signal transducer and activator of transcription 3	Homo sapiens	127-132	
19638453-8	2009	Cotreatment of HNSCC cells with bortezomib and guggulsterone, a naturally occurring compound known to inhibit STAT3 activation, led to synergistic activation of cell death and loss of clonogenic survival.	pregna-4,17-diene-3,16-dione	47-60	signal transducer and activator of transcription 3	Homo sapiens	110-115	
19020709-12	2008	The results of this study suggest that guggulsterone not only induces apoptosis, but also inhibits angiogenesis and metastasis in colon cancer cells by blocking STAT3 and VEGF expression, suggesting its therapeutic potential in the treatment of colorectal cancer.	pregna-4,17-diene-3,16-dione	39-52	signal transducer and activator of transcription 3	Homo sapiens	161-166	
18519703-0	2008	Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.	pregna-4,17-diene-3,16-dione	0-13	signal transducer and activator of transcription 3	Homo sapiens	86-91	
18519703-9	2008	Overall, these results suggest that GS is a novel blocker of STAT3 activation and thus may have a potential in regulation of growth and metastasis of tumor cells.	pregna-4,17-diene-3,16-dione	36-38	signal transducer and activator of transcription 3	Homo sapiens	61-66