PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17671214-2	2007	We now show that guggulsterone-induced cell death in human prostate cancer cells is caused by reactive oxygen intermediate (ROI)-dependent activation of c-Jun NH(2)-terminal kinase (JNK).	pregna-4,17-diene-3,16-dione	17-30	mitogen-activated protein kinase 8	Homo sapiens	153-180	
17671214-7	2007	The guggulsterone-induced JNK activation as well as cell death in prostate cancer cells was significantly attenuated by overexpression of catalase and superoxide dismutase.	pregna-4,17-diene-3,16-dione	4-17	mitogen-activated protein kinase 8	Homo sapiens	26-29	
17671214-9	2007	In conclusion, the present study reveals that the guggulsterone-induced cell death in human prostate cancer cells is regulated by ROI-dependent activation of JNK and guggulsterone inhibits promoter activity of androgen receptor.	pregna-4,17-diene-3,16-dione	50-63	mitogen-activated protein kinase 8	Homo sapiens	158-161	
17671214-2	2007	We now show that guggulsterone-induced cell death in human prostate cancer cells is caused by reactive oxygen intermediate (ROI)-dependent activation of c-Jun NH(2)-terminal kinase (JNK).	pregna-4,17-diene-3,16-dione	17-30	mitogen-activated protein kinase 8	Homo sapiens	182-185	
17671214-3	2007	Exposure of PC-3 and LNCaP cells to apoptosis inducing concentrations of guggulsterone resulted in activation of JNK and p38 mitogen-activated protein kinase (p38 MAPK) in both cell lines and activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in LNCaP cells.	pregna-4,17-diene-3,16-dione	73-86	mitogen-activated protein kinase 8	Homo sapiens	113-116	
17671214-4	2007	The guggulsterone-induced apoptosis in PC-3/LNCaP cells was partially but statistically significantly attenuated by pharmacologic inhibition (SP600125) as well as genetic suppression of JNK activation.	pregna-4,17-diene-3,16-dione	4-17	mitogen-activated protein kinase 8	Homo sapiens	186-189	
17475222-8	2007	The apoptotic effects of guggulsterone were preceded by activation of JNK and downregulation of Akt activity.	pregna-4,17-diene-3,16-dione	25-38	mitogen-activated protein kinase 8	Homo sapiens	70-73	
17475222-9	2007	JNK was needed for guggulsterone-induced apoptosis, inasmuch as inhibition of JNK by pharmacological inhibitors or by genetic deletion of MKK4 (activator of JNK) abolished the activity.	pregna-4,17-diene-3,16-dione	19-32	mitogen-activated protein kinase 8	Homo sapiens	0-3	
17475222-9	2007	JNK was needed for guggulsterone-induced apoptosis, inasmuch as inhibition of JNK by pharmacological inhibitors or by genetic deletion of MKK4 (activator of JNK) abolished the activity.	pregna-4,17-diene-3,16-dione	19-32	mitogen-activated protein kinase 8	Homo sapiens	78-81	
17475222-9	2007	JNK was needed for guggulsterone-induced apoptosis, inasmuch as inhibition of JNK by pharmacological inhibitors or by genetic deletion of MKK4 (activator of JNK) abolished the activity.	pregna-4,17-diene-3,16-dione	19-32	mitogen-activated protein kinase 8	Homo sapiens	78-81	
17475222-10	2007	Overall, our results indicate that guggulsterone can inhibit cell proliferation and induce apoptosis through the activation of JNK, suppression of Akt, and downregulation of antiapoptotic protein expression.	pregna-4,17-diene-3,16-dione	35-48	mitogen-activated protein kinase 8	Homo sapiens	127-130