PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23593498-10 2013 Further, LY37 significantly increased the phosphorylation, but not total protein, of extracellular signal-regulated kinase 1/2 (ERK1/2). LY 379268 9-13 mitogen-activated protein kinase 1 Homo sapiens 85-126 17293559-4 2007 Both in control astrocytes and in astrocytes exposed to OGD, CCPA and LY379268 induced a rapid activation of the phosphatidylinositol-3-kinase (PI3K) and extracellular signal-regulated kinases 1 and 2 (ERK1/2)/mitogen-activated protein kinase (MAPK) pathways, which are known to support cell survival. LY 379268 70-78 mitogen-activated protein kinase 1 Homo sapiens 154-200 17293559-5 2007 In cultures exposed to OGD, CCPA and LY379268 reduced the activation of c-Jun N-terminal kinase and p38/MAPK, reduced the levels of the proapoptotic protein Bad, increased the levels of the antiapoptotic protein Bcl-X(L), and were highly protective against apoptotic death, as shown by nuclear 4"-6-diamidino-2-phenylindole staining and measurements of caspase-3 activity. LY 379268 37-45 mitogen-activated protein kinase 1 Homo sapiens 100-103