PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34416343-0 2021 Rescue of BDNF Expression by the Thalamic Parafascicular Nucleus with Chronic Treatment with the mGluR2/3 Agonist LY379268 may Contribute to the LY379268 Rescue of Enkephalinergic Striatal Projection Neurons in R6/2 Huntington"s Disease Mice. LY 379268 114-122 brain derived neurotrophic factor Mus musculus 10-14 21505039-6 2011 Treatment with LY379268 also increased the amount of Gadd45-beta bound to specific promoter regions of reelin, brain-derived neurotrophic factor (BDNF), and glutamate decarboxylase-67 (GAD67). LY 379268 15-23 brain derived neurotrophic factor Mus musculus 111-144 21505039-6 2011 Treatment with LY379268 also increased the amount of Gadd45-beta bound to specific promoter regions of reelin, brain-derived neurotrophic factor (BDNF), and glutamate decarboxylase-67 (GAD67). LY 379268 15-23 brain derived neurotrophic factor Mus musculus 146-150 19909793-0 2010 Group II metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain. LY 379268 63-71 brain derived neurotrophic factor Mus musculus 110-143 19909793-3 2010 By using in situ hybridization and western blotting methods the aim of present study was to analyse the potential regulatory role of selective mGluR2/3 agonist LY379268 treatment on brain derived neurotrophic factor (BDNF) expression in the mouse brain. LY 379268 160-168 brain derived neurotrophic factor Mus musculus 182-215 19909793-3 2010 By using in situ hybridization and western blotting methods the aim of present study was to analyse the potential regulatory role of selective mGluR2/3 agonist LY379268 treatment on brain derived neurotrophic factor (BDNF) expression in the mouse brain. LY 379268 160-168 brain derived neurotrophic factor Mus musculus 217-221 19909793-4 2010 The treatment with LY379268 evidenced a significant upregulation of BDNF mRNA levels in the cerebral cortex and in the hippocampal formation with a peak at 3 h from treatment and its disappearance already at 6 h from treatment. LY 379268 19-27 brain derived neurotrophic factor Mus musculus 68-72 19909793-5 2010 An analysis of dose-effect curve revealed that LY379268 may significantly enhance BDNF mRNA expression already at dose of 0.250 mg/kg b.w. LY 379268 47-55 brain derived neurotrophic factor Mus musculus 82-86 19909793-6 2010 The upregulation of BDNF mRNA expression was followed by a significant increase of BDNF protein levels at 24 h from LY379268 treatment. LY 379268 116-124 brain derived neurotrophic factor Mus musculus 20-24 19909793-6 2010 The upregulation of BDNF mRNA expression was followed by a significant increase of BDNF protein levels at 24 h from LY379268 treatment. LY 379268 116-124 brain derived neurotrophic factor Mus musculus 83-87 19909793-7 2010 These effects of LY379268 treatment on BDNF expression were restricted to neuronal cells and were blocked by the new selective mGlu2/3 receptor antagonist LY341495, suggesting a receptor specificity. LY 379268 17-25 brain derived neurotrophic factor Mus musculus 39-43 34416343-0 2021 Rescue of BDNF Expression by the Thalamic Parafascicular Nucleus with Chronic Treatment with the mGluR2/3 Agonist LY379268 may Contribute to the LY379268 Rescue of Enkephalinergic Striatal Projection Neurons in R6/2 Huntington"s Disease Mice. LY 379268 145-153 brain derived neurotrophic factor Mus musculus 10-14 34416343-2 2021 We also previously showed that the benefit of daily LY379268 in R6/2 mice was associated with increases in corticostriatal brain-derived neurotrophic factor (BDNF), and in particular was associated with a reduction in enkephalinergic striatal projection neuron loss. LY 379268 52-60 brain derived neurotrophic factor Mus musculus 123-156 34416343-2 2021 We also previously showed that the benefit of daily LY379268 in R6/2 mice was associated with increases in corticostriatal brain-derived neurotrophic factor (BDNF), and in particular was associated with a reduction in enkephalinergic striatal projection neuron loss. LY 379268 52-60 brain derived neurotrophic factor Mus musculus 158-162 34416343-3 2021 In the present study, we show that daily LY379268 also rescues expression of BDNF by neurons of the thalamic parafascicular nucleus in R6/2 mice, which projects prominently to the striatum, and this increase too is linked to the rescue of enkephalinergic striatal neurons. LY 379268 41-49 brain derived neurotrophic factor Mus musculus 77-81 34416343-4 2021 Thus, LY379268 may protect enkephalinergic striatal projection neurons from loss by boosting BDNF production and delivery via both the corticostriatal and thalamostriatal projection systems. LY 379268 6-14 brain derived neurotrophic factor Mus musculus 93-97 28495373-7 2017 LY379268 induced brain-derived neurotrophic factor (BDNF) expression in astrocytes, and neutralizing BDNF from conditioned medium also prevented its neuroprotective effect on Abeta neurotoxicity. LY 379268 0-8 brain derived neurotrophic factor Mus musculus 17-50 30564095-6 2018 Treatment with the selective mGlu2/3 receptors agonist LY379268 also increased the amount of Gadd45-beta bound to specific promoter regions of reelin, BDNF, and GAD67. LY 379268 55-63 brain derived neurotrophic factor Mus musculus 151-155 28495373-7 2017 LY379268 induced brain-derived neurotrophic factor (BDNF) expression in astrocytes, and neutralizing BDNF from conditioned medium also prevented its neuroprotective effect on Abeta neurotoxicity. LY 379268 0-8 brain derived neurotrophic factor Mus musculus 52-56 23958449-6 2013 Moreover, activation of mGluR2/3 receptors by the selective group II metabotropic receptor agonist LY379268 abolished BDNF-induced cognitive enhancement suggesting the involvement of presynaptic glutamatergic activity. LY 379268 99-107 brain derived neurotrophic factor Mus musculus 118-122 22820300-0 2012 BDNF may play a differential role in the protective effect of the mGluR2/3 agonist LY379268 on striatal projection neurons in R6/2 Huntington"s disease mice. LY 379268 83-91 brain derived neurotrophic factor Mus musculus 0-4 22820300-4 2012 We found that LY379268 increased BDNF expression in layer 5 neurons in motor cortex, which project to striatum, partly rescued a preferential loss of enkephalinergic striatal neurons, and enhanced substance P (SP) expression by SP striatal projection neurons. LY 379268 14-22 brain derived neurotrophic factor Mus musculus 33-37 22820300-6 2012 Thus, LY379268 may protect the two main striatal projection neuron types by different mechanisms, enkephalinergic neurons by the trophic benefit of BDNF, and SP neurons by a mechanism not involving BDNF. LY 379268 6-14 brain derived neurotrophic factor Mus musculus 148-152