PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34932238-1 2022 BACKGROUND: Ozanimod, a high selective sphingosine 1 phosphate (S1P) receptor (S1PR) 1/5 modulator was approved by the Food and Drug Administration for the treatment of adult patients with moderately to severely active ulcerative colitis. ozanimod 12-20 sphingosine-1-phosphate receptor 1 Homo sapiens 79-88 34007159-3 2021 Ozanimod is an oral drug belonging to the sphingosine-1-phosphate receptor (S1PR) modulator family recently approved in different countries for MS with active disease. ozanimod 0-8 sphingosine-1-phosphate receptor 1 Homo sapiens 76-80 34007159-8 2021 This article retraces the itinerary leading to the approval of ozanimod for MS treatment and its peculiarities and potentiality inside the S1PR modulator family. ozanimod 63-71 sphingosine-1-phosphate receptor 1 Homo sapiens 139-143 32570252-11 2020 Ozanimod, an S1PR1 and S1PR5 inhibitor, has been successfully tested in initial studies in UC. ozanimod 0-8 sphingosine-1-phosphate receptor 1 Homo sapiens 13-18 31317509-11 2019 Similarly, ozanimod, an S1P1 and S1P5 receptor agonist, has shown early favorable results and is enrolling in phase III trials. ozanimod 11-19 sphingosine-1-phosphate receptor 1 Homo sapiens 24-46 33658933-2 2020 As a novel, orally available sphingosine 1-phosphate receptor modulator, ozanimod selectively binds to S1P1 and S1P5 receptor with high affinity, minimizing safety concerns caused by S1P3 receptor activation. ozanimod 73-81 sphingosine-1-phosphate receptor 1 Homo sapiens 103-107 32810927-2 2020 The latter is exploited in the approval and/or late-stage development of receptor-desensitizing agents targeting the S1P1 receptor in multiple sclerosis, such as siponimod, ozanimod and ponesimod. ozanimod 173-181 sphingosine-1-phosphate receptor 1 Homo sapiens 117-121 26990079-0 2016 Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity. ozanimod 0-8 sphingosine-1-phosphate receptor 1 Homo sapiens 31-65 26990079-0 2016 Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity. ozanimod 0-8 sphingosine-1-phosphate receptor 1 Homo sapiens 67-71