PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32401534-4	2020	As results, the nChap-based nanovaccine can elicits both CD4+ and CD8+ T cell-based immune responses and shows excellent preventive effect on melanoma.	nanovaccine	28-39	CD8a molecule	Homo sapiens	66-69	
33016303-3	2021	The nanovaccine could not only provide effective initial antigen stimulation and sustained long-term antigen supply with a controlled release, but also induce antigen cross-presentation via the MHC-I pathway initiating CD8+ T-cell responses.	nanovaccine	4-15	CD8a molecule	Homo sapiens	219-222	
32982219-10	2020	The polyanhydride nanovaccine results in protective CD8+ T cell responses as measured by inhibition of tumor progression and survival.	nanovaccine	18-29	CD8a molecule	Homo sapiens	52-55	
32982219-11	2020	Discussion: Together, these results suggest that the use of a polyanhydride-based nanovaccine can be an effective approach to inducing antigen-specific CD8+ T cell memory by providing antigen delivery and DC activation while avoiding overt inflammatory responses typically associated with traditional adjuvants.	nanovaccine	82-93	CD8a molecule	Homo sapiens	152-155	
32973811-3	2020	This nanovaccine was inoculated into humanized mice that mimic the human immune system (HIS) and possess functional iNKT cells and CD8+ T cells, called HIS-CD8/NKT mice.	nanovaccine	5-16	CD8a molecule	Homo sapiens	131-134	
32973811-4	2020	We found that multiple immunizations of HIS-CD8/NKT mice with the nanovaccine resulted in the activation and/or expansion of human CD141+ DCs and iNKT cells and ultimately elicited a potent Melan-A-specific CD8+ T cell response, as determined by tetramer staining and ELISpot assay.	nanovaccine	66-77	CD8a molecule	Homo sapiens	44-47	
32973811-5	2020	Single-cell proteomics further detailed the highly polyfunctional CD8+ T cells induced by the nanovaccine and revealed their predictive potential for vaccine potency.	nanovaccine	94-105	CD8a molecule	Homo sapiens	66-69	
29493121-6	2018	The results demonstrate that pHLIP-functionalized model nanovaccine can induce endolysosomal escape and enhance CD8+ T cell activation both in vitro and in vivo.	nanovaccine	56-67	CD8a molecule	Homo sapiens	112-115	
29493121-7	2018	Furthermore, based on the adjuvant-induced antigen assembly, nanovaccines of the clinically relevant tumor-associated antigen NY-ESO-1 are generated and show excellent capacity to elicit NY-ESO-1-specific CD8+ T cell activation, demonstrating a high potential of this functionalizable nanovaccine formulation strategy for clinical applications.	nanovaccine	61-72	CD8a molecule	Homo sapiens	205-208