PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25747583-3 2015 In this study, we describe the discovery of a novel PKD small molecule inhibitor, SD-208, from a targeted kinase inhibitor library screen, and the synthesis of a series of analogs to probe the structure-activity relationship (SAR) vs. PKD1. SD-208 82-88 polycystin 1, transient receptor potential channel interacting Homo sapiens 235-239 25747583-5 2015 Targeted inhibition of PKD by SD-208 resulted in potent inhibition of cell proliferation, an effect that could be reversed by overexpressed PKD1 or PKD3. SD-208 30-36 polycystin 1, transient receptor potential channel interacting Homo sapiens 140-144