PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9371780-8 1997 Finally, our data indicated that the feedback signal controlling Hmg2p ubiquitination and degradation was derived from farnesyl diphosphate, and thus implied conservation of an HMG-R degradation signal between yeast and mammals. farnesyl pyrophosphate 119-139 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 Saccharomyces cerevisiae S288C 65-70 19776008-3 2009 We had previously shown that alterations in cellular levels of the 15-carbon sterol pathway intermediate farnesyl pyrophosphate (FPP) cause increased Hmg2p ubiquitination and degradation. farnesyl pyrophosphate 105-127 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 Saccharomyces cerevisiae S288C 150-155 19776008-3 2009 We had previously shown that alterations in cellular levels of the 15-carbon sterol pathway intermediate farnesyl pyrophosphate (FPP) cause increased Hmg2p ubiquitination and degradation. farnesyl pyrophosphate 129-132 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 Saccharomyces cerevisiae S288C 150-155 19776008-4 2009 We now present evidence that the FPP-derived, 20-carbon molecule geranylgeranyl pyrophosphate (GGPP) is a potent endogenous regulator of Hmg2p degradation. farnesyl pyrophosphate 33-36 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 Saccharomyces cerevisiae S288C 137-142 10531376-4 1999 We now demonstrate that farnesyl diphosphate (FPP) is the source of the positive signal for Hmg2p degradation in yeast. farnesyl pyrophosphate 24-44 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 Saccharomyces cerevisiae S288C 92-97 10531376-4 1999 We now demonstrate that farnesyl diphosphate (FPP) is the source of the positive signal for Hmg2p degradation in yeast. farnesyl pyrophosphate 46-49 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 Saccharomyces cerevisiae S288C 92-97