PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19151033-12	2009	Treatment with L-mevalonate or farnesylpyrophosphate, but not geranylgeranyl-pyrophosphate reversed the statin-induced effect on CRP-mediated functions and ERK 1/2 phosphorylation, confirming that statins blocked CRP-induced ERK 1/2 phosphorylation through the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.	farnesyl pyrophosphate	31-52	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	275-332	
25497898-2	2015	Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production is catalyzed by 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.	farnesyl pyrophosphate	0-21	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	129-179	
14598891-3	2003	We have recently reported that 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, which block the biosynthesis of farnesylpyrophosphate and geranylgeranylpyrophosphate, inhibit in vitro invasion of human pancreatic cancer cells.	farnesyl pyrophosphate	133-154	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	31-88	
27133418-4	2016	The observation that the levels of FPP and GGPP, but not that of cholesterol, are elevated in AD patients is consistent with the finding that statins, competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, reduce FPP and GGPP levels and amyloid beta protein production in preclinical studies.	farnesyl pyrophosphate	35-38	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	177-234	
27133418-4	2016	The observation that the levels of FPP and GGPP, but not that of cholesterol, are elevated in AD patients is consistent with the finding that statins, competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, reduce FPP and GGPP levels and amyloid beta protein production in preclinical studies.	farnesyl pyrophosphate	243-246	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	177-234	
26425463-1	2015	Statins or 3-hydroxy-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors not only prevents the synthesis of cholesterol biosynthesis but also inhibits the synthesis of essential isoprenoid intermediates such as farnesyl pyrophosphate, geranylgeranyl pyrophosphate, isopentanyl adenosine, dolichols and polyisoprenoid side chains of ubiquinone, heme A, and nuclear lamins.	farnesyl pyrophosphate	216-238	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	11-66	
12454262-4	2002	However, during the last years several lines of evidence pointed to the existence of a second isoform of HMGCR localized in peroxisomes, where mevalonate is converted further to farnesyl diphosphate.	farnesyl pyrophosphate	178-198	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	105-110	
25497898-2	2015	Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production is catalyzed by 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.	farnesyl pyrophosphate	23-26	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	129-179	
22492974-4	2012	Because statin-induced inhibition of HMGCR reduces the production of substrates for isoprenylation-geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP)-the effects of GGPP and FPP were also evaluated.	farnesyl pyrophosphate	139-161	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	37-42	
22492974-4	2012	Because statin-induced inhibition of HMGCR reduces the production of substrates for isoprenylation-geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP)-the effects of GGPP and FPP were also evaluated.	farnesyl pyrophosphate	163-166	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	37-42	
22492974-4	2012	Because statin-induced inhibition of HMGCR reduces the production of substrates for isoprenylation-geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP)-the effects of GGPP and FPP were also evaluated.	farnesyl pyrophosphate	192-195	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	37-42	
21605082-8	2011	In the presence of lovastatin, an HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitor, both intracellular FPP levels and PPARgamma-target gene expressions were decreased.	farnesyl pyrophosphate	115-118	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	43-84	
19903814-8	2010	Furthermore, we show that the 3-hydroxy-3-methylglutaryl-CoA-reductase inhibitor mevastatin, which blocks FPP formation, not only promotes epithelialization in acute wounds but also reverses the effect of ZGA on activation of the GR and inhibition of epithelialization.	farnesyl pyrophosphate	106-109	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	30-70	
21586555-2	2011	Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	178-200	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	16-69	
21586555-2	2011	Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	178-200	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	71-76	
21586555-2	2011	Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	202-205	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	16-69	
21586555-2	2011	Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	202-205	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	71-76	
21586555-9	2011	Simultaneous HMGCR inhibition prevented the accumulation of FPP and restored osteoblast differentiation.	farnesyl pyrophosphate	60-63	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	13-18