PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25209804-7	2015	Similar ADMA dose- and time-dependent increases were detected in intracellular caspase-4 activity and macrophage apoptosis, all of which were sensitive to treatment with siRNAs for protein kinase RNA-like ER kinase and inositol-requiring protein-1 (IRE1), the ADMA antagonist L-arginine, as well as inhibitors of eukaryotic translation initiation factor-2 (salubrinal), IRE1 (irestatin 9389), and c-Jun N-terminal kinase (SP600125).	N,N-dimethylarginine	8-12	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	219-247	
25209804-7	2015	Similar ADMA dose- and time-dependent increases were detected in intracellular caspase-4 activity and macrophage apoptosis, all of which were sensitive to treatment with siRNAs for protein kinase RNA-like ER kinase and inositol-requiring protein-1 (IRE1), the ADMA antagonist L-arginine, as well as inhibitors of eukaryotic translation initiation factor-2 (salubrinal), IRE1 (irestatin 9389), and c-Jun N-terminal kinase (SP600125).	N,N-dimethylarginine	8-12	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	249-253	
25209804-7	2015	Similar ADMA dose- and time-dependent increases were detected in intracellular caspase-4 activity and macrophage apoptosis, all of which were sensitive to treatment with siRNAs for protein kinase RNA-like ER kinase and inositol-requiring protein-1 (IRE1), the ADMA antagonist L-arginine, as well as inhibitors of eukaryotic translation initiation factor-2 (salubrinal), IRE1 (irestatin 9389), and c-Jun N-terminal kinase (SP600125).	N,N-dimethylarginine	8-12	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	370-374	
24451129-4	2014	We found that ADMA treatment activated the endoplasmic reticulum (ER) stress sensor proteins phosphorylated protein kinase RNA-activated-like ER kinase (PERK) and inositol requiring-1alpha (IRE1), which correspondingly induced C/EBP homologous protein (CHOP) expression and phosphorylated c-Jun N-terminal kinase (JNK) phosphorylation in glomerular endothelial cells (GEnCs).	N,N-dimethylarginine	14-18	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	190-194	
24451129-7	2014	QC prevented ADMA-induced PERK and IRE1 apoptotic ER stress pathway activation.	N,N-dimethylarginine	13-17	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	35-39	
24451129-10	2014	Overall, these observations indicate that ADMA may induce GEnCs apoptosis and TGF-beta expression by targeting the PERK-CHOP and IRE1-JNK pathway.	N,N-dimethylarginine	42-46	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	129-133