PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21438403-0 2010 [Effect of ginsenoside Rg1 on expressions of phosphory protein tau and N-methyl-D-aspartate receptor subunits NR1 and NR2B in rat brain slice model of Alzheimer"s disease]. ginsenoside Rg1 11-26 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 110-113 21438403-1 2010 OBJECTIVE: To investigate the effect of ginsenoside Rg1 on the expressions of phosphory protein Tau (P-Tau), N-methyl-D-aspartate receptor subunit 1 (NR1) and N-methyl-D-aspartate receptor subunit 2B(NR2B) in rat brain slice model of Alzheimer"s disease. ginsenoside Rg1 40-55 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 109-148 21438403-1 2010 OBJECTIVE: To investigate the effect of ginsenoside Rg1 on the expressions of phosphory protein Tau (P-Tau), N-methyl-D-aspartate receptor subunit 1 (NR1) and N-methyl-D-aspartate receptor subunit 2B(NR2B) in rat brain slice model of Alzheimer"s disease. ginsenoside Rg1 40-55 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 150-153 21438403-10 2010 Compared with the untreated group, the expression of P-Tau was significantly decreased (P < 0.01 or P < 0.05) and the expressions of NR1 and NR2B were increased (P < 0.01 or P < 0.05) in ginsenoside Rg1 groups, especially in high-dose ginsenoside Rg1 group. ginsenoside Rg1 187-202 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 133-136 21438403-11 2010 CONCLUSION: Ginsenoside Rg1 can play the role of anti-dementia by inhibiting the expression of P-Tau so as to slow the formation of neurofibrillary tangles and increasing the expression of NR1 and NR2B so as to improve learning and memory abilities in rat brain slice model of Alzheimer"s disease. ginsenoside Rg1 12-27 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 189-192