PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26587553-4	2015	RESULTS: We found that in vitro exposure of human monocytes to fingolimod inhibited LPS-induced CD25 and CD150 expression and tumor necrosis factor-alpha (TNF-alpha) secretion without altering immune cell survival.	Fingolimod Hydrochloride	63-73	tumor necrosis factor	Homo sapiens	126-153	
26587553-4	2015	RESULTS: We found that in vitro exposure of human monocytes to fingolimod inhibited LPS-induced CD25 and CD150 expression and tumor necrosis factor-alpha (TNF-alpha) secretion without altering immune cell survival.	Fingolimod Hydrochloride	63-73	tumor necrosis factor	Homo sapiens	155-164	
26587553-5	2015	Further, EAE treatment with fingolimod led to reduced amounts of TNF-alpha produced by myeloid cells in vivo in the spleen and CNS.	Fingolimod Hydrochloride	28-38	tumor necrosis factor	Homo sapiens	65-74	
19328962-2	2009	We showed that clinically relevant concentrations of FTY720 inhibited TNF-alpha-induced SMC proliferation and extracellular signal-regulated kinase (ERK) phosphorylation.	Fingolimod Hydrochloride	53-59	tumor necrosis factor	Homo sapiens	70-79	
10344723-2	1999	In this study we investigated whether FTY720 was able to induce apoptosis in an androgen-independent prostate cancer cell line, DU145, which is not only resistant to androgen-withdrawal-induced apoptosis but also Fas- and TNF-alpha-mediated apoptosis.	Fingolimod Hydrochloride	38-44	tumor necrosis factor	Homo sapiens	222-231	
34007158-9	2021	FTY720 reduced the secretion of IL-1beta, IL-6, and IL-8 from TNF-alpha-stimulated MH7A cells in a dose-dependent manner.	Fingolimod Hydrochloride	0-6	tumor necrosis factor	Homo sapiens	62-71	
34007158-10	2021	FTY720 also inhibited TNF-alpha-induced phosphorylation of NF-kappaBp65 and IkappaBalpha, as well as NF-kappaBp65 nuclear translocation, in a dose- and time-dependent manner.	Fingolimod Hydrochloride	0-6	tumor necrosis factor	Homo sapiens	22-31	
34007158-13	2021	Our data also indicated that FTY720 inhibited TNF-alpha-induced inflammation by suppressing the AKT/PI3K/NF-kappaB pathway in MH7A cells.	Fingolimod Hydrochloride	29-35	tumor necrosis factor	Homo sapiens	46-55	
31526917-5	2019	CCL2 (p = 0.039), and CCL5 (p = 0.001) levels were significantly higher in fingolimod-treated patients than healthy controls, whereas end-of-study serum levels of IL-6, IL-8, IL-17A, IL-22, IL-23, TNF-alpha, CXCL10, and CXCL13 were comparable to the baseline levels.	Fingolimod Hydrochloride	75-85	tumor necrosis factor	Homo sapiens	197-206	
31228713-14	2019	B cells from Fingolimod-treated patients induced a reduction in pro-inflammatory cytokines in T cells, while increased transforming growth factor beta (TGFbeta)+ B and T cells, and downregulated IL2-secretion from proliferative T cells.	Fingolimod Hydrochloride	13-23	tumor necrosis factor	Homo sapiens	119-150	
26931477-5	2016	Fingolimod dramatically reduced tumour necrosis factor (TNF)-induced endothelial microparticle release in vitro.	Fingolimod Hydrochloride	0-10	tumor necrosis factor	Homo sapiens	32-54	
26931477-5	2016	Fingolimod dramatically reduced tumour necrosis factor (TNF)-induced endothelial microparticle release in vitro.	Fingolimod Hydrochloride	0-10	tumor necrosis factor	Homo sapiens	56-59