PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30005970-0	2018	Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages.	Fingolimod Hydrochloride	40-50	RPTOR independent companion of MTOR, complex 2	Mus musculus	30-36	
30005970-0	2018	Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages.	Fingolimod Hydrochloride	52-58	RPTOR independent companion of MTOR, complex 2	Mus musculus	30-36	
30005970-5	2018	Here we showed that a fungus metabolite Fingolimod (FTY720, Gilenya), which is clinically approved for the treatment of multiple sclerosis, down-regulates Rictor, which is a signature molecule of mTORC2 and dictates its substrate (actin cytoskeleton) specificity, down-regulates RhoA, up-regulates PAK-1, and causes amplification of podosomes in mouse peritoneal macrophages.	Fingolimod Hydrochloride	40-50	RPTOR independent companion of MTOR, complex 2	Mus musculus	155-161