PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25720064-1	2015	FTY720 (fingolimod) is, after its phosphorylation by sphingosine kinase (SPHK) 2, a potent, non-selective sphingosine-1-phosphate (S1P) receptor agonist.	Fingolimod Hydrochloride	0-6	sphingosine kinase 2	Mus musculus	53-80	
31123291-0	2019	Sphingosine Kinase 2 Phosphorylation of FTY720 is Unnecessary for Prevention of Light-Induced Retinal Damage.	Fingolimod Hydrochloride	40-46	sphingosine kinase 2	Mus musculus	0-20	
31123291-6	2019	Additionally, FTY720 treatment protected Sphk2 KO retinas from light-induced damage despite significant retardation of FTY720 phosphorylation in Sphk2 KO mice.	Fingolimod Hydrochloride	14-20	sphingosine kinase 2	Mus musculus	41-46	
31123291-6	2019	Additionally, FTY720 treatment protected Sphk2 KO retinas from light-induced damage despite significant retardation of FTY720 phosphorylation in Sphk2 KO mice.	Fingolimod Hydrochloride	14-20	sphingosine kinase 2	Mus musculus	145-150	
26719367-3	2016	Sphingosine kinases (Sphk1, Sphk2) phosphorylate FTY720 in vivo to form the bioactive metabolite FTY720-1-phosphate (FTY720-P).	Fingolimod Hydrochloride	49-55	sphingosine kinase 2	Mus musculus	28-33	
26719367-7	2016	Treatment of LM/Bc MEFs with FTY720 and a selective Sphk2 inhibitor, ABC294640, significantly reduces the amount of FTY720-P that accumulates in the nucleus.	Fingolimod Hydrochloride	29-35	sphingosine kinase 2	Mus musculus	52-57	
25720064-1	2015	FTY720 (fingolimod) is, after its phosphorylation by sphingosine kinase (SPHK) 2, a potent, non-selective sphingosine-1-phosphate (S1P) receptor agonist.	Fingolimod Hydrochloride	8-18	sphingosine kinase 2	Mus musculus	53-80	
23667698-2	2013	Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs.	Fingolimod Hydrochloride	31-37	sphingosine kinase 2	Mus musculus	97-117	
23667698-2	2013	Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs.	Fingolimod Hydrochloride	31-37	sphingosine kinase 2	Mus musculus	119-124	
21872577-3	2011	Particularly, SphK2 is necessary for the phosphorylation of the sphingosine analog fingolimod (FTY720), which is protective in rodent stroke models.	Fingolimod Hydrochloride	83-93	sphingosine kinase 2	Mus musculus	14-19	
16093248-5	2005	Although FTY720 was selectively activated in vivo by SPHK2, other S1P pro-drugs can be phosphorylated to cause lymphopenia through the action of additional sphingosine kinases.	Fingolimod Hydrochloride	9-15	sphingosine kinase 2	Mus musculus	53-58