PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31399186-3	2019	Fingolimod, whose active metabolite, fingolimod phosphate, acts as a nonselective S1P-receptor agonist, exerts its immunomodulatory effect, at least in part, by regulating lymphocyte trafficking via downregulation of S1P1 expression on lymphocytes.	Fingolimod Hydrochloride	0-10	sphingosine-1-phosphate receptor 1	Rattus norvegicus	217-221	
29380527-3	2018	In this study, we tested the hypothesis that FTY720, a sphingosine 1-phosphate (S1P) analogue used for treating multiple sclerosis, modulates the up-regulation of P-gp and improves brain delivery of phenytoin (PHT) through S1P receptor 1 in the hippocampus of a pilocarpine-induced rat model of status epilepticus (SE).	Fingolimod Hydrochloride	45-51	sphingosine-1-phosphate receptor 1	Rattus norvegicus	223-237	
29377379-7	2018	Applying a potent S1P-S1PR1 signaling modulator, Fingolimod (FTY720), in a Wistar rat apical periodontitis model effectively prevented bone lesions in vivo via downregulation of RANKL production, osteoclastogenesis, and bone resorption.	Fingolimod Hydrochloride	49-59	sphingosine-1-phosphate receptor 1	Rattus norvegicus	22-27	
29377379-7	2018	Applying a potent S1P-S1PR1 signaling modulator, Fingolimod (FTY720), in a Wistar rat apical periodontitis model effectively prevented bone lesions in vivo via downregulation of RANKL production, osteoclastogenesis, and bone resorption.	Fingolimod Hydrochloride	61-67	sphingosine-1-phosphate receptor 1	Rattus norvegicus	22-27	
28054340-11	2017	Fingolimod treatment improved functional and morphological outcomes after GMH, in part, by tempering acute post-hemorrhagic blood-brain barrier disruption via the activation of the S1PR1/Akt/Rac1 pathway.	Fingolimod Hydrochloride	0-10	sphingosine-1-phosphate receptor 1	Rattus norvegicus	181-186	
27083962-2	2016	FTY720, an agonist of the sphingosine-1-phosphate receptor 1 (S1PR1), inhibits apoptosis in ischemic stroke.	Fingolimod Hydrochloride	0-6	sphingosine-1-phosphate receptor 1	Rattus norvegicus	26-60	
27083962-2	2016	FTY720, an agonist of the sphingosine-1-phosphate receptor 1 (S1PR1), inhibits apoptosis in ischemic stroke.	Fingolimod Hydrochloride	0-6	sphingosine-1-phosphate receptor 1	Rattus norvegicus	62-67	
25880547-11	2015	Moreover, after a 1-h pretreatment with FTY720 (an agonist for S1PR1/R3/R4/R5), neither SEW2871 (S1PR1 selective agonist) nor S1P augmented the excitability.	Fingolimod Hydrochloride	40-46	sphingosine-1-phosphate receptor 1	Rattus norvegicus	63-68	
25347187-2	2014	S1P1 is a major regulator of lymphocyte trafficking, and fingolimod, whose active metabolite fingolimod phosphate acts as a nonselective S1P receptor agonist, exerts its immunomodulatory effect, at least in part, by regulating the lymphocyte trafficking by inducing down regulation of lymphocyte S1P1.	Fingolimod Hydrochloride	57-67	sphingosine-1-phosphate receptor 1	Rattus norvegicus	296-300	
22828274-0	2012	Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1/S1PR3 pathway.	Fingolimod Hydrochloride	0-10	sphingosine-1-phosphate receptor 1	Rattus norvegicus	99-104	
22828274-5	2012	We then compared siRNA and/or fingolimod (100 nM) treatments on PDGFR-beta, S1PR1 S1PR2 and S1PR3 expression.	Fingolimod Hydrochloride	30-40	sphingosine-1-phosphate receptor 1	Rattus norvegicus	76-81	
22828274-10	2012	As an S1P analogue, fingolimod is considered a potent activator of S1PR1 and S1PR3.	Fingolimod Hydrochloride	20-30	sphingosine-1-phosphate receptor 1	Rattus norvegicus	67-72	
23285242-7	2012	infusion of FTY720 (0.1, 0.3, 1.0 mg/kg/20 min) or BAF312 (0.5, 1.5, 5.0 mg/kg/20 min) elicited acute bradycardia in anesthetized rats demonstrating an S1P1 mediated mechanism-of-action.	Fingolimod Hydrochloride	12-18	sphingosine-1-phosphate receptor 1	Rattus norvegicus	152-156	
22916176-4	2012	We hypothesized that FTY720 might exert the cardioprotective effects of S1P1 and S1P3 viaprotein kinase C-beta (PKCbeta II) signaling pathway.	Fingolimod Hydrochloride	21-27	sphingosine-1-phosphate receptor 1	Rattus norvegicus	72-85	
20032465-8	2010	The PKC activator phorbol 12-myristate 13-acetate partially rescued FTY720-induced down-regulation of the S1P(1) receptor, linking PKC activation with S1P(1) receptor surface expression.	Fingolimod Hydrochloride	68-74	sphingosine-1-phosphate receptor 1	Rattus norvegicus	106-112	
20032465-8	2010	The PKC activator phorbol 12-myristate 13-acetate partially rescued FTY720-induced down-regulation of the S1P(1) receptor, linking PKC activation with S1P(1) receptor surface expression.	Fingolimod Hydrochloride	68-74	sphingosine-1-phosphate receptor 1	Rattus norvegicus	151-157	
32259820-5	2020	However, Fingolimod, an S1P1 inhibitor, could reverse these Floralozone effects in experimental atherosclerotic rats.	Fingolimod Hydrochloride	9-19	sphingosine-1-phosphate receptor 1	Rattus norvegicus	24-28