PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22580711-6 2012 Western blot analysis showed that FTY720 induced the downregulation of cyclin D1, cyclin E, CDK2, CDK4, Bcl-2 and E2F1 and the upregulation of Kip1/p27, Cip1/p21, Bax and Rb in GMC in a dose-dependent manner. Fingolimod Hydrochloride 34-40 E2F transcription factor 1 Rattus norvegicus 114-118