PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30843214-0	2019	FTY720 alleviates coxsackievirus B3-induced myocarditis and inhibits viral replication through regulating sphingosine 1-phosphate receptors and AKT/caspase-3 pathways.	Fingolimod Hydrochloride	0-6	caspase 3	Homo sapiens	148-157	
18281497-7	2008	Equally important, pharmacologic inhibition or shRNA-mediated knockdown of PKC delta protected FTY720-treated Huh7 cells from caspase-3 activation.	Fingolimod Hydrochloride	95-101	caspase 3	Homo sapiens	126-135	
25344679-9	2014	Western blot analysis showed that FTY720 induced cleavage of caspases 3, 8 and 9, and of PARP, in a dose-dependent manner, consistent with a substantial decrease in p-STAT3, Bcl-xL, Bcl-2, survivin, cyclin D1, cyclin E, N-cadherin, vimentin, VEGF and TWIST1.	Fingolimod Hydrochloride	34-40	caspase 3	Homo sapiens	61-80	
22281442-4	2012	We observed that FTY720 could induce caspase-3 dependent apoptosis in a dose- and time-dependent manner in U266 cells.	Fingolimod Hydrochloride	17-23	caspase 3	Homo sapiens	37-46	
18281497-10	2008	Blockade of ROS production by an NADPH oxidase inhibitor protected Huh7 cells from FTY720-induced PKC delta activation and caspase-3-dependent apoptosis.	Fingolimod Hydrochloride	83-89	caspase 3	Homo sapiens	123-132	
12711631-17	2003	OA partially inhibited FTY720-induced caspase-3 activation.	Fingolimod Hydrochloride	23-29	caspase 3	Homo sapiens	38-47	
11857403-3	2002	We previously reported that FTY720, a metabolite from Isaria sinclarii, is a unique antitumor agent for an androgen-independent prostate cancer cell line and requires caspase-3 activation in apoptosis.	Fingolimod Hydrochloride	28-34	caspase 3	Homo sapiens	167-176	
10344723-8	1999	Furthermore, FTY720-induced apoptosis was prevented by caspase-3 inhibitor.	Fingolimod Hydrochloride	13-19	caspase 3	Homo sapiens	55-64