PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34337080-0 2021 Exosomes Derived from Nerve Stem Cells Loaded with FTY720 Promote the Recovery after Spinal Cord Injury in Rats by PTEN/AKT Signal Pathway. Fingolimod Hydrochloride 51-57 AKT serine/threonine kinase 1 Rattus norvegicus 120-123 28054340-11 2017 Fingolimod treatment improved functional and morphological outcomes after GMH, in part, by tempering acute post-hemorrhagic blood-brain barrier disruption via the activation of the S1PR1/Akt/Rac1 pathway. Fingolimod Hydrochloride 0-10 AKT serine/threonine kinase 1 Rattus norvegicus 187-190 35274449-0 2022 Fingolimod ameliorates acetic acid-induced ulcerative colitis: An insight into its modulatory impact on pro/anti-inflammatory cytokines and AKT/mTOR signalling. Fingolimod Hydrochloride 0-10 AKT serine/threonine kinase 1 Rattus norvegicus 140-143 35274449-1 2022 BACKGROUND: Because of the approved immunomodulatory activities of fingolimod, the current study aimed at studying the curative potential of fingolimod against experimentally induced ulcerative colitis (UC) via modulating pro/anti-inflammatory cytokines release and AKT/mTOR signalling. Fingolimod Hydrochloride 141-151 AKT serine/threonine kinase 1 Rattus norvegicus 266-269 35274449-10 2022 In addition, fingolimod decreased the expressions of AKT and mTOR compared to the UC group. Fingolimod Hydrochloride 13-23 AKT serine/threonine kinase 1 Rattus norvegicus 53-56 35274449-11 2022 CONCLUSION: Fingolimod attenuated acetic acid-induced UC through its immunomodulatory effect by shifting the balance to favour anti-inflammatory cytokine production rather than pro-inflammatory cytokines and modulating the AKT/mTOR signalling. Fingolimod Hydrochloride 12-22 AKT serine/threonine kinase 1 Rattus norvegicus 223-226