PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1816091-2	1991	Since a number of central neurotransmitters are also known to influence glucose levels and it is likely that CNS insulin receptors act through neurotransmitter mediation, the present study was conducted to investigate the effect of intracerebroventricularly (icv) administered insulin on rat brain dopamine (DA), noradrenaline (NA), serotonin and acetylcholine (ACh) activity in normal and alloxan-induced hyperglycaemic animals.	icv	259-262	insulin	Homo sapiens	113-120	
27730514-0	2017	Intranasal Insulin Administration Ameliorates Streptozotocin (ICV)-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Memory Impairment in Rats.	icv	62-65	insulin	Homo sapiens	11-18	
27730514-7	2017	Moreover, intranasal insulin was found to inhibit significantly glial cell activation (GFAP and Iba-1 expression), neuroinflammation (COX-2 expression, NFkappaB translocation, TNF-alpha, and IL-10 level) and amyloidogenic protein expression (BACE-1 and Abeta1-42 expression) in STZ (ICV)-injected rats.	icv	283-286	insulin	Homo sapiens	21-28	
27730514-8	2017	STZ (ICV)-induced caspase activation and postsynaptic neurotoxicity were also prevented by treatment with intranasal insulin.	icv	5-8	insulin	Homo sapiens	117-124	
27730514-10	2017	Graphical Abstract Neuroprotective effects of intranasal insulin administration on streptozotocin (ICV)-induced memory impairment in rats.	icv	99-102	insulin	Homo sapiens	57-64