PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30576423-2 2019 We previously found that mitochondrial protein FUNDC2 mediates phosphoinositide 3-kinase (PI3K)/phosphatidylinositol-3,4,5-trisphosphate (PIP3)-dependent AKT phosphorylation and regulates platelet apoptosis. phosphatidylinositol 3,4,5-triphosphate 96-136 thymoma viral proto-oncogene 1 Mus musculus 154-157 32086008-1 2020 Phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3] is a phosphorylated derivative of phosphatidylinositol 4-phosphate [PI(4)P] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], which recruit and activate AKT in the plasma membrane (PM) to promote cellular survival. phosphatidylinositol 3,4,5-triphosphate 0-40 thymoma viral proto-oncogene 1 Mus musculus 213-216 33276499-2 2020 Class I PI3K generates PtdIns(3,4,5)P3 at the plasma membrane in response to growth factor stimulation, leading to AKT activation to drive cell proliferation, survival and migration. phosphatidylinositol 3,4,5-triphosphate 23-38 thymoma viral proto-oncogene 1 Mus musculus 115-118 33276499-3 2020 PTEN negatively regulates PI3K/AKT signalling by dephosphorylating PtdIns(3,4,5)P3 to form PtdIns(4,5)P2. phosphatidylinositol 3,4,5-triphosphate 67-82 thymoma viral proto-oncogene 1 Mus musculus 31-34 24658595-2 2014 By acting as a unique lipid phosphatase converting phosphatidylinositol-3,4,5,- trisphosphate (PIP3) to phosphatidylinositol-4,5,-bisphosphate (PIP2), phosphatase and tensin homolog (PTEN) acts as the major cellular suppressor of PI3K signaling and AKT activation. phosphatidylinositol 3,4,5-triphosphate 51-93 thymoma viral proto-oncogene 1 Mus musculus 249-252 30692625-5 2019 Mechanistically, the interaction of phosphatidylinositol (3,4,5)-trisphosphate with AKT facilitates its interaction with SETDB1 for subsequent AKT methylation, which in turn sustains AKT phosphorylation. phosphatidylinositol 3,4,5-triphosphate 36-78 thymoma viral proto-oncogene 1 Mus musculus 84-87 30692625-5 2019 Mechanistically, the interaction of phosphatidylinositol (3,4,5)-trisphosphate with AKT facilitates its interaction with SETDB1 for subsequent AKT methylation, which in turn sustains AKT phosphorylation. phosphatidylinositol 3,4,5-triphosphate 36-78 thymoma viral proto-oncogene 1 Mus musculus 143-146 30692625-5 2019 Mechanistically, the interaction of phosphatidylinositol (3,4,5)-trisphosphate with AKT facilitates its interaction with SETDB1 for subsequent AKT methylation, which in turn sustains AKT phosphorylation. phosphatidylinositol 3,4,5-triphosphate 36-78 thymoma viral proto-oncogene 1 Mus musculus 143-146 28250113-8 2017 Quantitative fluorescence microscopy showed that phosphatidylinositol (3,4,5)-trisphosphate (PIP3), a product of PI3K and an upstream activator of Akt, localized to macropinocytic cups and that pAkt occurred primarily in cups. phosphatidylinositol 3,4,5-triphosphate 49-91 thymoma viral proto-oncogene 1 Mus musculus 147-150 24805236-2 2014 PTEN dephosphorylates phosphatidylinositol (3,4,5)-triphosphate, thereby opposing the activity of class I phosphatidylinositol 3-kinases that mediate growth- and survival-factor signalling through phosphatidylinositol 3-kinase effectors such as AKT and mTOR. phosphatidylinositol 3,4,5-triphosphate 22-63 thymoma viral proto-oncogene 1 Mus musculus 245-248 28650469-13 2017 Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT/GSK3beta signaling axis at cilia in SHH-dependent medulloblastoma that is regulated by INPP5E to maintain tumor cell cilia, promote SHH signaling and thereby medulloblastoma progression. phosphatidylinositol 3,4,5-triphosphate 51-66 thymoma viral proto-oncogene 1 Mus musculus 67-70 29035165-3 2017 PI3Ks phosphorylate phosphatidylinositol 4,5-biphosphate (PIP2) yielding phosphatidylinositol 3, 4, 5 triphosphate (PIP3) which in turn activate AKT kinase (serine/threonine kinase), the central enzyme in regulation of metabolic functions. phosphatidylinositol 3,4,5-triphosphate 73-114 thymoma viral proto-oncogene 1 Mus musculus 145-148 24392697-4 2014 One of the most studied tumor suppressors in these pathways is the lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten), which dephosphorylates the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate (PIP3), thus preventing activation of the oncogenic kinase AKT (v-akt murine thymoma viral oncogene homolog). phosphatidylinositol 3,4,5-triphosphate 200-240 thymoma viral proto-oncogene 1 Mus musculus 300-303 21775285-2 2011 Akt is activated during growth factor stimulation through a process that requires binding of Akt to phosphatidylinositol 3,4,5-trisphosphate (PIP(3)), which promotes membrane localization and phosphorylation of Akt by the upstream kinase PDK1 (phosphoinositide-dependent protein kinase 1). phosphatidylinositol 3,4,5-triphosphate 100-140 thymoma viral proto-oncogene 1 Mus musculus 0-3 23275438-1 2013 3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, including protein kinase B (PKB)/Akt. phosphatidylinositol 3,4,5-triphosphate 127-167 thymoma viral proto-oncogene 1 Mus musculus 248-264 23275438-1 2013 3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, including protein kinase B (PKB)/Akt. phosphatidylinositol 3,4,5-triphosphate 127-167 thymoma viral proto-oncogene 1 Mus musculus 266-269 23275438-1 2013 3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, including protein kinase B (PKB)/Akt. phosphatidylinositol 3,4,5-triphosphate 127-167 thymoma viral proto-oncogene 1 Mus musculus 271-274 23275438-1 2013 3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, including protein kinase B (PKB)/Akt. phosphatidylinositol 3,4,5-triphosphate 169-186 thymoma viral proto-oncogene 1 Mus musculus 248-264 23275438-1 2013 3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, including protein kinase B (PKB)/Akt. phosphatidylinositol 3,4,5-triphosphate 169-186 thymoma viral proto-oncogene 1 Mus musculus 266-269 23275438-1 2013 3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, including protein kinase B (PKB)/Akt. phosphatidylinositol 3,4,5-triphosphate 169-186 thymoma viral proto-oncogene 1 Mus musculus 271-274 23359699-6 2013 Additive effects of 20:4-PC and LY294002 were not observed, underlining the critical role of Akt for 20:4-PC signaling; 20:4-PC suppressed Akt membrane translocation as shown by immunofluorescence microscopy but left the concentration of the anchor lipid phosphatidylinositol-3,4,5-trisphosphate unchanged. phosphatidylinositol 3,4,5-triphosphate 255-295 thymoma viral proto-oncogene 1 Mus musculus 139-142 22965143-0 2012 A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability. phosphatidylinositol 3,4,5-triphosphate 20-62 thymoma viral proto-oncogene 1 Mus musculus 73-76 22965143-3 2012 OBJECTIVE: By investigating phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 (P-Rex1), one of the Rac-specific guanine nucleotide exchange factors previously known for G protein-coupled receptor signaling, we sought to determine whether Rac-guanine nucleotide exchange factor is nodal for signal integration and potential target for drug intervention. phosphatidylinositol 3,4,5-triphosphate 28-70 thymoma viral proto-oncogene 1 Mus musculus 81-84 22965143-3 2012 OBJECTIVE: By investigating phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 (P-Rex1), one of the Rac-specific guanine nucleotide exchange factors previously known for G protein-coupled receptor signaling, we sought to determine whether Rac-guanine nucleotide exchange factor is nodal for signal integration and potential target for drug intervention. phosphatidylinositol 3,4,5-triphosphate 28-70 thymoma viral proto-oncogene 1 Mus musculus 118-121 22965143-3 2012 OBJECTIVE: By investigating phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 (P-Rex1), one of the Rac-specific guanine nucleotide exchange factors previously known for G protein-coupled receptor signaling, we sought to determine whether Rac-guanine nucleotide exchange factor is nodal for signal integration and potential target for drug intervention. phosphatidylinositol 3,4,5-triphosphate 28-70 thymoma viral proto-oncogene 1 Mus musculus 118-121 25485494-2 2014 Both PDK1 and PKB can interact at the plasma membrane with a phosphoinositide synthesized by PI3K, the second messenger PtdIns(3,4,5)P3, enabling PDK1 to phosphorylate and activate PKB. phosphatidylinositol 3,4,5-triphosphate 120-135 thymoma viral proto-oncogene 1 Mus musculus 14-17 25485494-2 2014 Both PDK1 and PKB can interact at the plasma membrane with a phosphoinositide synthesized by PI3K, the second messenger PtdIns(3,4,5)P3, enabling PDK1 to phosphorylate and activate PKB. phosphatidylinositol 3,4,5-triphosphate 120-135 thymoma viral proto-oncogene 1 Mus musculus 181-184 21775285-2 2011 Akt is activated during growth factor stimulation through a process that requires binding of Akt to phosphatidylinositol 3,4,5-trisphosphate (PIP(3)), which promotes membrane localization and phosphorylation of Akt by the upstream kinase PDK1 (phosphoinositide-dependent protein kinase 1). phosphatidylinositol 3,4,5-triphosphate 100-140 thymoma viral proto-oncogene 1 Mus musculus 93-96 21775285-2 2011 Akt is activated during growth factor stimulation through a process that requires binding of Akt to phosphatidylinositol 3,4,5-trisphosphate (PIP(3)), which promotes membrane localization and phosphorylation of Akt by the upstream kinase PDK1 (phosphoinositide-dependent protein kinase 1). phosphatidylinositol 3,4,5-triphosphate 100-140 thymoma viral proto-oncogene 1 Mus musculus 93-96 12900409-6 2003 Phosphatidylinositol 3,4,5-trisphosphate (PIP3), the primary regulator of Akt, increases significantly in GqWT-expressing cells but not in cardiomyocytes expressing GqQ209L. phosphatidylinositol 3,4,5-triphosphate 0-40 thymoma viral proto-oncogene 1 Mus musculus 74-77 18339867-2 2008 Most of the tumor suppressor function of PTEN has been attributed to its ability to dephosphorylate the second messenger, phosphatidylinositol 3,4,5-triphosphate, resulting in the biological control of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway. phosphatidylinositol 3,4,5-triphosphate 122-161 thymoma viral proto-oncogene 1 Mus musculus 243-246 17720808-2 2007 In particular, reciprocal activation of phosphatidylinositol 3-kinases (PI3Ks) and small GTPases like Rac leads to accumulation, at the leading edge, of the PI3K product phosphatidylinositol 3,4,5-trisphosphate (PIP3). phosphatidylinositol 3,4,5-triphosphate 170-210 thymoma viral proto-oncogene 1 Mus musculus 102-105 21464312-1 2011 The phosphatidylinositol-3,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic Akt/PKB kinase. phosphatidylinositol 3,4,5-triphosphate 4-43 thymoma viral proto-oncogene 1 Mus musculus 148-151 21464312-1 2011 The phosphatidylinositol-3,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic Akt/PKB kinase. phosphatidylinositol 3,4,5-triphosphate 4-43 thymoma viral proto-oncogene 1 Mus musculus 152-155 17258189-5 2007 Downstream effectors of phosphatidylinositol-(3,4,5)-triphosphate in sperm include the protein kinases, Akt and PKCzeta. phosphatidylinositol 3,4,5-triphosphate 24-65 thymoma viral proto-oncogene 1 Mus musculus 104-107 16880400-4 2006 This increased Akt activity correlates with increased phosphatidylinositol (3,4,5)-trisphosphate levels which are due, at least in part, to diminished activity of the (3,4,5)-trisphosphate phosphatase PTEN. phosphatidylinositol 3,4,5-triphosphate 54-96 thymoma viral proto-oncogene 1 Mus musculus 15-18 11551825-4 2001 ATDC5 cells produced phosphatidylinositol 3,4,5-trisphosphate and the pleckstrin homology domain of PKB was recruited to the plasma membrane in response to insulin stimulation. phosphatidylinositol 3,4,5-triphosphate 21-61 thymoma viral proto-oncogene 1 Mus musculus 100-103 10224144-4 1999 Co-clustering of sIg-FcgammaRIIb transmits a dominant negative signal and is associated with reduced accumulation of the PtdIns 3-kinase product phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3), known to be a potent activator of Akt. phosphatidylinositol 3,4,5-triphosphate 145-185 thymoma viral proto-oncogene 1 Mus musculus 239-242 10224144-4 1999 Co-clustering of sIg-FcgammaRIIb transmits a dominant negative signal and is associated with reduced accumulation of the PtdIns 3-kinase product phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3), known to be a potent activator of Akt. phosphatidylinositol 3,4,5-triphosphate 187-202 thymoma viral proto-oncogene 1 Mus musculus 239-242 10224144-6 1999 We hypothesized that the decreased Akt activity arises from the consumption of PtdIns 3,4,5-P3 by the inositol-5-phosphatase Src homology 2-containing inositol 5-phosphatase (SHIP), which has been shown by us to be tyrosine-phosphorylated and associated with FcgammaRIIb when the latter is co-ligated. phosphatidylinositol 3,4,5-triphosphate 79-94 thymoma viral proto-oncogene 1 Mus musculus 35-38