PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29138419-3 2017 It"s signals are mediated by SHIP (Src homology 2-containing inositol 5" phosphatase), in particular SHIP1, which activation leads to hydrolyzation of PIP3 (Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3, leading to the inhibition of calcium mobilization and to the attenuation of mast cell activation. phosphatidylinositol 3,4,5-triphosphate 201-216 inositol polyphosphate-5-phosphatase D Mus musculus 29-33 29138419-3 2017 It"s signals are mediated by SHIP (Src homology 2-containing inositol 5" phosphatase), in particular SHIP1, which activation leads to hydrolyzation of PIP3 (Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3, leading to the inhibition of calcium mobilization and to the attenuation of mast cell activation. phosphatidylinositol 3,4,5-triphosphate 201-216 inositol polyphosphate-5-phosphatase D Mus musculus 35-84 29138419-3 2017 It"s signals are mediated by SHIP (Src homology 2-containing inositol 5" phosphatase), in particular SHIP1, which activation leads to hydrolyzation of PIP3 (Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3, leading to the inhibition of calcium mobilization and to the attenuation of mast cell activation. phosphatidylinositol 3,4,5-triphosphate 201-216 inositol polyphosphate-5-phosphatase D Mus musculus 101-106 22651931-1 2012 SH2 domain-containing inositol-5"-phosphatase-1 (SHIP1) inhibits inflammation by hydrolyzing phosphoinositide-3"-kinase generated membrane phosphatidylinositol-3,4,5-trisphosphate (PIP(3)). phosphatidylinositol 3,4,5-triphosphate 139-179 inositol polyphosphate-5-phosphatase D Mus musculus 0-47 22651931-1 2012 SH2 domain-containing inositol-5"-phosphatase-1 (SHIP1) inhibits inflammation by hydrolyzing phosphoinositide-3"-kinase generated membrane phosphatidylinositol-3,4,5-trisphosphate (PIP(3)). phosphatidylinositol 3,4,5-triphosphate 139-179 inositol polyphosphate-5-phosphatase D Mus musculus 49-54 20147977-1 2010 SHIP-1 (SH2 (Src homology 2)-containing inositol 5"-phosphatase-1) functions as a negative regulator of immune responses by hydrolyzing phosphatidylinositol-3,4,5-triphosphate generated by phosphoinositide-3 (PI 3)-kinase activity. phosphatidylinositol 3,4,5-triphosphate 136-175 inositol polyphosphate-5-phosphatase D Mus musculus 0-6 21725061-8 2011 Because SHIP-1 is a major negative regulator of the phosphatidylinositol-3-kinase pathway in lymphocytes, we hypothesize that the interaction between SHIP-1 and CIN85 might synergistically facilitate the down-regulation of phosphatidylinositol-3,4,5-trisphosphate levels. phosphatidylinositol 3,4,5-triphosphate 223-263 inositol polyphosphate-5-phosphatase D Mus musculus 8-14 21725061-8 2011 Because SHIP-1 is a major negative regulator of the phosphatidylinositol-3-kinase pathway in lymphocytes, we hypothesize that the interaction between SHIP-1 and CIN85 might synergistically facilitate the down-regulation of phosphatidylinositol-3,4,5-trisphosphate levels. phosphatidylinositol 3,4,5-triphosphate 223-263 inositol polyphosphate-5-phosphatase D Mus musculus 150-156 20154203-5 2010 This immature phenotype of SHIP(-/-) DCs could be reversed with the PI3K inhibitors LY294002 and wortmannin, suggesting that SHIP promotes DC maturation by reducing the levels of the PI3K second messenger phosphatidylinositol-3,4,5-trisphosphate. phosphatidylinositol 3,4,5-triphosphate 205-245 inositol polyphosphate-5-phosphatase D Mus musculus 27-31 20154203-5 2010 This immature phenotype of SHIP(-/-) DCs could be reversed with the PI3K inhibitors LY294002 and wortmannin, suggesting that SHIP promotes DC maturation by reducing the levels of the PI3K second messenger phosphatidylinositol-3,4,5-trisphosphate. phosphatidylinositol 3,4,5-triphosphate 205-245 inositol polyphosphate-5-phosphatase D Mus musculus 125-129 19542434-1 2009 SHIP1 inhibits immune receptor signaling through hydrolysis of the PI3K product phosphatidylinositol 3,4,5-trisphosphate, forming phosphatidylinositol 3,4-bisphosphate. phosphatidylinositol 3,4,5-triphosphate 80-120 inositol polyphosphate-5-phosphatase D Mus musculus 0-5 17682126-9 2007 In contrast, macrophages from Ship1(-/-)/AktPH-GFP transgenic mice exhibited increased and sustained PtdIns(3,4,5)P(3) at the cup in response to CR3 activation, with minimal changes to FcgammaR activation. phosphatidylinositol 3,4,5-triphosphate 101-118 inositol polyphosphate-5-phosphatase D Mus musculus 30-35 12161749-1 2002 The hematopoietic-restricted protein Src homology 2-containing inositol-5-phosphatase (SHIP) blunts phosphatidylinositol-3-kinase-initiated signaling by dephosphorylating its major substrate, phosphatidylinositol-3,4,5-trisphosphate. phosphatidylinositol 3,4,5-triphosphate 192-232 inositol polyphosphate-5-phosphatase D Mus musculus 37-85 12161749-1 2002 The hematopoietic-restricted protein Src homology 2-containing inositol-5-phosphatase (SHIP) blunts phosphatidylinositol-3-kinase-initiated signaling by dephosphorylating its major substrate, phosphatidylinositol-3,4,5-trisphosphate. phosphatidylinositol 3,4,5-triphosphate 192-232 inositol polyphosphate-5-phosphatase D Mus musculus 87-91 12008029-5 2002 SHIP acts as a negative regulator of degranulation by hydrolyzing phosphatidylinositol-3,4,5-trisphosphate, a second messenger generated in activated cells by phosphatidylinositol 3-kinase. phosphatidylinositol 3,4,5-triphosphate 66-106 inositol polyphosphate-5-phosphatase D Mus musculus 0-4 10354708-1 1999 The recently cloned, hemopoietic-specific, src homology 2 (SH2)-containing inositol phosphatase, SHIP, is rapidly gaining prominence as a potential regulator of all phosphatidylinositol (PI)-3 kinase mediated events since it has been shown both in vitro and in vivo to hydrolyze the 5" phosphate from phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3). phosphatidylinositol 3,4,5-triphosphate 301-341 inositol polyphosphate-5-phosphatase D Mus musculus 97-101 17371235-2 2007 PtdIns(3,4,5)P(3) is also metabolized by removal of the 5-phosphate catalysed by a distinct family of enzymes exemplified by SHIP1 [SH2 (Src homology 2)-containing inositol phosphatase 1] and SHIP2. phosphatidylinositol 3,4,5-triphosphate 0-17 inositol polyphosphate-5-phosphatase D Mus musculus 125-130 17347685-3 2007 Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1) is a 5-phosphatase capable of dephosphorylating the phosphatidylinositol 3,4,5-trisphosphate second messenger into phosphatidylinositol 3,4-bisphosphate. phosphatidylinositol 3,4,5-triphosphate 118-158 inositol polyphosphate-5-phosphatase D Mus musculus 0-57 17347685-3 2007 Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1) is a 5-phosphatase capable of dephosphorylating the phosphatidylinositol 3,4,5-trisphosphate second messenger into phosphatidylinositol 3,4-bisphosphate. phosphatidylinositol 3,4,5-triphosphate 118-158 inositol polyphosphate-5-phosphatase D Mus musculus 59-64 17173042-8 2007 By directing where PtdIns(3,4,5)P(3) accumulates, SHIP1 governs the formation of the leading edge and polarization required for chemotaxis. phosphatidylinositol 3,4,5-triphosphate 19-36 inositol polyphosphate-5-phosphatase D Mus musculus 50-55 15944314-1 2005 The SHIP converts phosphatidylinositol 3,4,5 triphosphate to phosphatidyl 3,4 biphosphate. phosphatidylinositol 3,4,5-triphosphate 18-57 inositol polyphosphate-5-phosphatase D Mus musculus 4-8 15166241-4 2004 Our studies on murine SHIP1 knockout platelets have defined a major role for this enzyme in regulating integrin alpha(IIb)beta(3)-dependent phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) accumulation, necessary for a cytosolic calcium response and platelet spreading. phosphatidylinositol 3,4,5-triphosphate 140-180 inositol polyphosphate-5-phosphatase D Mus musculus 22-27 15166241-4 2004 Our studies on murine SHIP1 knockout platelets have defined a major role for this enzyme in regulating integrin alpha(IIb)beta(3)-dependent phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) accumulation, necessary for a cytosolic calcium response and platelet spreading. phosphatidylinositol 3,4,5-triphosphate 182-200 inositol polyphosphate-5-phosphatase D Mus musculus 22-27 15210764-7 2004 The loss of SHIP phosphorylation and activity very likely contributes to the increased levels of phosphatidylinositol 3,4,5-trisphosphate and the excess FcepsilonRI signaling in Lyn(-/-) BMMCs. phosphatidylinositol 3,4,5-triphosphate 97-137 inositol polyphosphate-5-phosphatase D Mus musculus 12-16 11781306-1 2002 Using bone marrow derived mast cells from SH2-containing inositol-5-phosphatase (SHIP) +/+ and minus sign/minus sign mice, we found that the loss of SHIP leads to a dramatic increase in Steel Factor (SF)-stimulated phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)), a substantial reduction in PI(3,4)P(2), and no change in PI(4,5)P(2) levels. phosphatidylinositol 3,4,5-triphosphate 215-255 inositol polyphosphate-5-phosphatase D Mus musculus 149-153 10790429-3 2000 We demonstrate a critical role for SHIP in termination of phosphatidylinositol 3,4,5-triphosphate (PI[3,4,5]P(3)) signals that follow BCR aggregation. phosphatidylinositol 3,4,5-triphosphate 58-97 inositol polyphosphate-5-phosphatase D Mus musculus 35-39 10610720-3 1999 Recent results suggest that SHIP2 and SHIP1 act downstream of various receptors by removing a phosphate from the 5" position of the phosphatidylinositol 3"-kinase phosphatidylinositol 3,4, 5-triphosphate product and of inositol 1,3,4,5-tetrakisphosphate. phosphatidylinositol 3,4,5-triphosphate 163-203 inositol polyphosphate-5-phosphatase D Mus musculus 38-43 10224144-6 1999 We hypothesized that the decreased Akt activity arises from the consumption of PtdIns 3,4,5-P3 by the inositol-5-phosphatase Src homology 2-containing inositol 5-phosphatase (SHIP), which has been shown by us to be tyrosine-phosphorylated and associated with FcgammaRIIb when the latter is co-ligated. phosphatidylinositol 3,4,5-triphosphate 79-94 inositol polyphosphate-5-phosphatase D Mus musculus 175-179