PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31570383-3	2020	PTEN encodes a dual lipid and protein phosphatase that dephosphorylates the lipid phosphatidylinositol-3,4,5-trisphosphate (PIP3), in turn negatively regulating the oncogenic PI3K-AKT pathway, a key proto-oncogenic player in cancer development and progression.	phosphatidylinositol 3,4,5-triphosphate	82-122	phosphatase and tensin homolog	Mus musculus	0-4	
33276499-3	2020	PTEN negatively regulates PI3K/AKT signalling by dephosphorylating PtdIns(3,4,5)P3 to form PtdIns(4,5)P2.	phosphatidylinositol 3,4,5-triphosphate	67-82	phosphatase and tensin homolog	Mus musculus	0-4	
33065020-2	2020	While the role of PTEN lipid-phosphatase activity on PtdIns(3,4,5)P3 and inhibition of PI3K pathway is well characterized, the biological relevance of PTEN protein-phosphatase activity remains undefined.	phosphatidylinositol 3,4,5-triphosphate	53-68	phosphatase and tensin homolog	Mus musculus	18-22	
24658595-2	2014	By acting as a unique lipid phosphatase converting phosphatidylinositol-3,4,5,- trisphosphate (PIP3) to phosphatidylinositol-4,5,-bisphosphate (PIP2), phosphatase and tensin homolog (PTEN) acts as the major cellular suppressor of PI3K signaling and AKT activation.	phosphatidylinositol 3,4,5-triphosphate	51-93	phosphatase and tensin homolog	Mus musculus	183-187	
25520316-5	2015	Enhanced O2 - led to activation of the phosphatases PTP1B and PTEN, which via dephosphorylation of the IGF-1 receptor and phosphatidylinositol 3,4,5-triphosphate dampened IGF-1 signalling.	phosphatidylinositol 3,4,5-triphosphate	122-161	phosphatase and tensin homolog	Mus musculus	62-66	
24805236-2	2014	PTEN dephosphorylates phosphatidylinositol (3,4,5)-triphosphate, thereby opposing the activity of class I phosphatidylinositol 3-kinases that mediate growth- and survival-factor signalling through phosphatidylinositol 3-kinase effectors such as AKT and mTOR.	phosphatidylinositol 3,4,5-triphosphate	22-63	phosphatase and tensin homolog	Mus musculus	0-4	
24766807-2	2014	Here, we show that PTEN homodimerizes and, in this active conformation, exerts lipid phosphatase activity on PtdIns(3,4,5)P3.	phosphatidylinositol 3,4,5-triphosphate	109-124	phosphatase and tensin homolog	Mus musculus	19-23	
24392697-4	2014	One of the most studied tumor suppressors in these pathways is the lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten), which dephosphorylates the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate (PIP3), thus preventing activation of the oncogenic kinase AKT (v-akt murine thymoma viral oncogene homolog).	phosphatidylinositol 3,4,5-triphosphate	200-240	phosphatase and tensin homolog	Mus musculus	85-89	
22150431-3	2012	PTEN is a phosphatase with selectivity for PtdIns(3,4,5)P3, which is produced by the class I isoforms of PI3K (p110alpha, p110beta, p110gamma and p110delta).	phosphatidylinositol 3,4,5-triphosphate	43-58	phosphatase and tensin homolog	Mus musculus	0-4	
24048858-3	2013	Conversely, PTEN (phosphatase and tensin homolog on chromosome 10) dephosphorylates PtdIns(3,4,5)P3 and negatively regulates the AKT pathway and myelination.	phosphatidylinositol 3,4,5-triphosphate	84-99	phosphatase and tensin homolog	Mus musculus	12-16	
19286998-3	2009	Phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) signaling in neutrophils was elevated by depleting PTEN, a phosphatidylinositol 3"-phosphatase that hydrolyzes PtdIns(3,4,5)P(3).	phosphatidylinositol 3,4,5-triphosphate	0-40	phosphatase and tensin homolog	Mus musculus	112-116	
21521784-8	2011	Together, these observations demonstrate that the innate immune responses can be enhanced and the severity of neutropenia-related infection can be alleviated by augmenting phosphatidylinositol (3,4,5)-trisphosphate in transfused neutrophils with PTEN inhibitor SF1670, providing a therapeutic strategy for improving the efficacy of granulocyte transfusion.	phosphatidylinositol 3,4,5-triphosphate	172-214	phosphatase and tensin homolog	Mus musculus	246-250	
21531890-3	2011	The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is phosphatidylinositol phosphate phosphatase, which negatively controls PI3K by dephosphorylating the signaling lipid, phosphatidylinositol 3,4,5-triphosphate.	phosphatidylinositol 3,4,5-triphosphate	187-226	phosphatase and tensin homolog	Mus musculus	61-65	
19875726-4	2009	For example, the PTEN (phosphatase and tensin homolog) tumor suppressor protein is a phosphoinositide 3-phosphatase that, by metabolizing phosphatidylinositol 3,4,5-trisphosphate (PtdIns[3,4,5]P(3), PIP3), acts in direct antagonism to growth factor-stimulated PI3K.	phosphatidylinositol 3,4,5-triphosphate	138-178	phosphatase and tensin homolog	Mus musculus	17-21	
21926349-4	2011	Here we report that dysregulation of PI3K signaling in mice by deletion of the phosphatase and tensin homolog (Pten) gene (which regulates the levels of the PI3K product, phosphatidylinositol 3,4,5-trisphosphate) caused mast cell hyperplasia and increased numbers in various organs.	phosphatidylinositol 3,4,5-triphosphate	171-211	phosphatase and tensin homolog	Mus musculus	111-115	
18794881-1	2008	The PTEN tumour suppressor is a lipid and protein phosphatase that inhibits phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)).	phosphatidylinositol 3,4,5-triphosphate	151-191	phosphatase and tensin homolog	Mus musculus	4-8	
18178811-1	2008	Control of the intracellular levels of phosphatidylinositol-(3, 4, 5)-trisphosphate by PI3K and phosphatase and tensin homolog (PTEN) is essential for B cell development and differentiation.	phosphatidylinositol 3,4,5-triphosphate	39-83	phosphatase and tensin homolog	Mus musculus	128-132	
18339867-2	2008	Most of the tumor suppressor function of PTEN has been attributed to its ability to dephosphorylate the second messenger, phosphatidylinositol 3,4,5-triphosphate, resulting in the biological control of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway.	phosphatidylinositol 3,4,5-triphosphate	122-161	phosphatase and tensin homolog	Mus musculus	41-45	
18201277-2	2008	The major substrate of PTEN is phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), a second messenger molecule produced following PI3K activation induced by a variety of stimuli.	phosphatidylinositol 3,4,5-triphosphate	31-71	phosphatase and tensin homolog	Mus musculus	23-27	
17195063-2	2007	The protein/lipid phosphatase Pten (phosphatase and tensin homologue deleted on chromosome 10) attenuates PI3K signalling by dephosphorylating the phosphatidylinositol 3,4,5-trisphosphate generated by PI3K.	phosphatidylinositol 3,4,5-triphosphate	147-187	phosphatase and tensin homolog	Mus musculus	30-34	
17371230-2	2007	The major substrate of PTEN is PIP(3) (phosphatidylinositol 3,4,5-trisphosphate) generated by the action of PI3Ks (phosphoinositide 3-kinases).	phosphatidylinositol 3,4,5-triphosphate	39-79	phosphatase and tensin homolog	Mus musculus	23-27	
17341655-2	2007	PTEN is a dual protein/lipid phosphatase and its main substrate phosphatidyl-inositol 3,4,5 triphosphate (PIP3) is the product of PI3K.	phosphatidylinositol 3,4,5-triphosphate	64-104	phosphatase and tensin homolog	Mus musculus	0-4	
16214396-1	2005	Phosphatase and tensin homolog (PTEN) is a multifunctional phosphatase whose substrate is phosphatidylinositol-3,4,5-triphosphate (PIP3), and it is also a ubiquitously expressed tumor suppressor gene that down-regulates phosphatidylinositol-3-kinases (PI3Ks).	phosphatidylinositol 3,4,5-triphosphate	90-129	phosphatase and tensin homolog	Mus musculus	32-36	
16880400-4	2006	This increased Akt activity correlates with increased phosphatidylinositol (3,4,5)-trisphosphate levels which are due, at least in part, to diminished activity of the (3,4,5)-trisphosphate phosphatase PTEN.	phosphatidylinositol 3,4,5-triphosphate	54-96	phosphatase and tensin homolog	Mus musculus	201-205	
15467489-7	2004	PTEN opposes the action of PI3-kinase by dephosphorylating the signaling lipid phosphatidylinositol 3,4,5-triphosphate.	phosphatidylinositol 3,4,5-triphosphate	79-118	phosphatase and tensin homolog	Mus musculus	0-4	
15289934-1	2004	The tumor suppressor function of PTEN is attributed to its phospholipid phosphatase activity that dephosphorylates the plasma membrane phosphatidylinositol-(3,4,5)-triphosphate [PtdIns(3,4,5)P3].	phosphatidylinositol 3,4,5-triphosphate	135-176	phosphatase and tensin homolog	Mus musculus	33-37	
15289934-1	2004	The tumor suppressor function of PTEN is attributed to its phospholipid phosphatase activity that dephosphorylates the plasma membrane phosphatidylinositol-(3,4,5)-triphosphate [PtdIns(3,4,5)P3].	phosphatidylinositol 3,4,5-triphosphate	178-193	phosphatase and tensin homolog	Mus musculus	33-37	
15289934-2	2004	Implicit in this notion is that PTEN needs to be targeted to the plasma membrane to dephosphorylate PtdIns(3,4,5)P3.	phosphatidylinositol 3,4,5-triphosphate	100-115	phosphatase and tensin homolog	Mus musculus	32-36	
12671058-2	2003	PTEN blocks the action of PI3K by dephosphorylating the signaling lipid phosphatidylinositol 3,4,5-triphosphate.	phosphatidylinositol 3,4,5-triphosphate	72-111	phosphatase and tensin homolog	Mus musculus	0-4	
12563260-1	2003	Phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN) phosphatase serve essential functions in the regulation of cell growth, differentiation and survival by modulating intracellular phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) concentrations.	phosphatidylinositol 3,4,5-triphosphate	204-244	phosphatase and tensin homolog	Mus musculus	69-73	
10339565-0	1999	PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.	phosphatidylinositol 3,4,5-triphosphate	70-111	phosphatase and tensin homolog	Mus musculus	0-4	
10339565-5	1999	Inactivation of PTEN in ES cells and in embryonic fibroblasts resulted in elevated levels of phosphatidylinositol 3,4,5,-trisphosphate, a product of phosphatidylinositol 3 kinase.	phosphatidylinositol 3,4,5-triphosphate	93-134	phosphatase and tensin homolog	Mus musculus	16-20	
10339565-8	1999	Our studies suggest that PTEN regulates the phosphatidylinositol 3,4, 5,-trisphosphate and Akt signaling pathway and consequently modulates two critical cellular processes: cell cycle progression and cell survival.	phosphatidylinositol 3,4,5-triphosphate	44-86	phosphatase and tensin homolog	Mus musculus	25-29	
12163562-7	2002	Similar alterations are seen in T cells from mice which are haploinsufficient for PTEN, a lipid phosphatase that regulates phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) and influences PKBalpha activity.	phosphatidylinositol 3,4,5-triphosphate	123-163	phosphatase and tensin homolog	Mus musculus	82-86	
11916922-2	2002	PTEN (MMAC1) is a lipid/protein phosphatase that can negatively regulate the PI3K pathway by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate, but it is unclear whether PTEN is physiologically relevant to insulin signaling in vivo.	phosphatidylinositol 3,4,5-triphosphate	111-152	phosphatase and tensin homolog	Mus musculus	0-4	
11916922-2	2002	PTEN (MMAC1) is a lipid/protein phosphatase that can negatively regulate the PI3K pathway by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate, but it is unclear whether PTEN is physiologically relevant to insulin signaling in vivo.	phosphatidylinositol 3,4,5-triphosphate	111-152	phosphatase and tensin homolog	Mus musculus	6-11	
9778245-5	1998	Furthermore, PTEN negatively regulates intracellular levels of phosphatidylinositol (3,4,5) trisphosphate in cells and dephosphorylates it in vitro.	phosphatidylinositol 3,4,5-triphosphate	63-105	phosphatase and tensin homolog	Mus musculus	13-17