PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33373654-0	2021	A Rho kinase inhibitor (Fasudil) suppresses TGF-beta mediated autophagy in urethra fibroblasts to attenuate traumatic urethral stricture (TUS) through re-activating Akt/mTOR pathway: An in vitro study.	fasudil	24-31	AKT serine/threonine kinase 1	Homo sapiens	165-168	
33373654-6	2021	In addition, TGF-beta treatment decreased the expression levels of phosphorylated Akt (p-Akt) and mTOR (p-mTOR) to inactivate the Akt/mTOR pathway in the PUFs, which could be re-activated by Fasudil.	fasudil	191-198	AKT serine/threonine kinase 1	Homo sapiens	82-85	
33373654-6	2021	In addition, TGF-beta treatment decreased the expression levels of phosphorylated Akt (p-Akt) and mTOR (p-mTOR) to inactivate the Akt/mTOR pathway in the PUFs, which could be re-activated by Fasudil.	fasudil	191-198	AKT serine/threonine kinase 1	Homo sapiens	89-92	
33373654-6	2021	In addition, TGF-beta treatment decreased the expression levels of phosphorylated Akt (p-Akt) and mTOR (p-mTOR) to inactivate the Akt/mTOR pathway in the PUFs, which could be re-activated by Fasudil.	fasudil	191-198	AKT serine/threonine kinase 1	Homo sapiens	89-92	
33373654-7	2021	Then, the fibroblasts were treated with the Pan-Akt inhibitor (GDC-0068), and we surprisingly found that GDC-0068 abrogated the inhibiting effects of Fasudil on cell autophagy and proliferation in the PUFs treated with TGF-beta.	fasudil	150-157	AKT serine/threonine kinase 1	Homo sapiens	48-51	
33373654-8	2021	SIGNIFICANCE: Fasudil regulated Akt/mTOR pathway mediated autophagy to hamper TGF-beta-mediated super-activation in PUFs, which supported that Fasudil might be an ideal candidate therapeutic agent for TUS treatment for clinical utilization.	fasudil	14-21	AKT serine/threonine kinase 1	Homo sapiens	32-35	
20126978-7	2010	Interestingly, EGF-induced phosphorylation of both Akt and glycogen synthase kinase-3beta (GSK-3beta), but not p44/p42 mitogen-activated protein (MAP) kinase, were dose-dependently enhanced when the cells were pretreated with Y27632 or fasudil, another Rho-kinase inhibitor.	fasudil	236-243	AKT serine/threonine kinase 1	Homo sapiens	51-54	
23118936-0	2012	Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways.	fasudil	0-7	AKT serine/threonine kinase 1	Homo sapiens	169-172