PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23118936-0 2012 Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways. fasudil 0-7 AKT serine/threonine kinase 1 Homo sapiens 169-172 33373654-0 2021 A Rho kinase inhibitor (Fasudil) suppresses TGF-beta mediated autophagy in urethra fibroblasts to attenuate traumatic urethral stricture (TUS) through re-activating Akt/mTOR pathway: An in vitro study. fasudil 24-31 AKT serine/threonine kinase 1 Homo sapiens 165-168 33373654-6 2021 In addition, TGF-beta treatment decreased the expression levels of phosphorylated Akt (p-Akt) and mTOR (p-mTOR) to inactivate the Akt/mTOR pathway in the PUFs, which could be re-activated by Fasudil. fasudil 191-198 AKT serine/threonine kinase 1 Homo sapiens 82-85 33373654-6 2021 In addition, TGF-beta treatment decreased the expression levels of phosphorylated Akt (p-Akt) and mTOR (p-mTOR) to inactivate the Akt/mTOR pathway in the PUFs, which could be re-activated by Fasudil. fasudil 191-198 AKT serine/threonine kinase 1 Homo sapiens 89-92 33373654-6 2021 In addition, TGF-beta treatment decreased the expression levels of phosphorylated Akt (p-Akt) and mTOR (p-mTOR) to inactivate the Akt/mTOR pathway in the PUFs, which could be re-activated by Fasudil. fasudil 191-198 AKT serine/threonine kinase 1 Homo sapiens 89-92 33373654-7 2021 Then, the fibroblasts were treated with the Pan-Akt inhibitor (GDC-0068), and we surprisingly found that GDC-0068 abrogated the inhibiting effects of Fasudil on cell autophagy and proliferation in the PUFs treated with TGF-beta. fasudil 150-157 AKT serine/threonine kinase 1 Homo sapiens 48-51 33373654-8 2021 SIGNIFICANCE: Fasudil regulated Akt/mTOR pathway mediated autophagy to hamper TGF-beta-mediated super-activation in PUFs, which supported that Fasudil might be an ideal candidate therapeutic agent for TUS treatment for clinical utilization. fasudil 14-21 AKT serine/threonine kinase 1 Homo sapiens 32-35 20126978-7 2010 Interestingly, EGF-induced phosphorylation of both Akt and glycogen synthase kinase-3beta (GSK-3beta), but not p44/p42 mitogen-activated protein (MAP) kinase, were dose-dependently enhanced when the cells were pretreated with Y27632 or fasudil, another Rho-kinase inhibitor. fasudil 236-243 AKT serine/threonine kinase 1 Homo sapiens 51-54