PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31859913-8	2020	Sciatic nerve M1 macrophages marker iNOS was decreased while M2 macrophages marker arginase-1 was increased in the Fasudil group at day 28.	fasudil	115-122	nitric oxide synthase 2, inducible	Mus musculus	36-40	
25908255-4	2015	The administration of Fasudil exhibited neuroprotective effects against the dopaminergic neurons and improved the motor function recovery in the MPTP-PD mice, accompanied by the suppression of inflammatory responses (IL-1beta, TNF-alpha, NF-kappaB-p65 and TLR-2), and oxidative stress (iNOS and gp91Phox), which might be associated with the inhibition of ROCK and GSK-3beta activity.	fasudil	22-29	nitric oxide synthase 2, inducible	Mus musculus	286-290	
26045742-9	2015	The expression of IL-1beta, TNF-alpha, TLR2 and p-NF-kappaB and iNOS were lower after fasudil treatment (P<0.05) while the expression of arginase1 was increased (P<0.05).	fasudil	86-93	nitric oxide synthase 2, inducible	Mus musculus	64-68	
28284330-7	2017	FPS-ZM1 and fasudil exerted their anti-inflammatory effects by downregulating inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), NLRP3 and nuclear translocation of nuclear factor kappa B (NF-kappaB) p65.	fasudil	12-19	nitric oxide synthase 2, inducible	Mus musculus	78-109	
28284330-7	2017	FPS-ZM1 and fasudil exerted their anti-inflammatory effects by downregulating inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), NLRP3 and nuclear translocation of nuclear factor kappa B (NF-kappaB) p65.	fasudil	12-19	nitric oxide synthase 2, inducible	Mus musculus	111-115	
25287052-5	2015	Fasudil also decreased levels of iNOS/NO, enhanced levels of Arg-1, and inhibited the TLR-4/NF-kappaB signaling and TNF-alpha, shifting M1 macrophage to M2 phenotype.	fasudil	0-7	nitric oxide synthase 2, inducible	Mus musculus	33-37	
23418431-6	2013	By using Western blot and immunohistochemistry, iNOS and Arg-1, as two most specific markers for M1 and M2, was inhibited or induced in splenic macrophages and spinal cords of EAE mice treated with Fasudil.	fasudil	198-205	nitric oxide synthase 2, inducible	Mus musculus	48-52	
22994384-5	2012	The ratio of arginase/iNOS was enhanced mainly in the spinal cords of EAE mice treated with Fasudil, reflecting a shift toward the M2 (antiinflammation) macrophage/microglia phenotype.	fasudil	92-99	nitric oxide synthase 2, inducible	Mus musculus	22-26