PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9858612-0 1999 Cyclosporin A promotes translational silencing of autocrine interleukin-3 via ribosome-associated deadenylation. Cyclosporine 0-13 interleukin 3 Homo sapiens 60-73 23024272-6 2012 The tissue specificity of these DHSs mirrored the activity of the IL-3 gene, and included a highly inducible cyclosporin A-sensitive enhancer at -37 kb that increased IL-3 promoter activity 40-fold. Cyclosporine 109-122 interleukin 3 Homo sapiens 167-171 14579277-4 2003 Only very high doses of cyclosporin A and FK506 inhibited macrophage proliferation induced by growth factors, such as M-CSF, granulocyte-macrophage (GM)-CSF or IL-3. Cyclosporine 24-37 interleukin 3 Homo sapiens 160-164 12165512-4 2002 The most conserved sequence lies 4.5 kb upstream of the IL-3 gene and it encompassed an inducible cyclosporin A-sensitive DH site. Cyclosporine 98-111 interleukin 3 Homo sapiens 56-60 12614449-8 2003 RESULTS: Ascomycin (0.01 nm to 1 micro m) and cyclosporin A (0.1 nm to 10 micro m) strikingly inhibited (maximally 100%) anti-IgE-induced histamine and cytokine release from basophils, and these actions were unaffected by IL-3 priming. Cyclosporine 46-59 interleukin 3 Homo sapiens 222-226 9858612-2 1999 Cyclosporin A (CsA), a calcineurin antagonist and blocker of interleukin-2 (IL-2) transcription in T cells, was found to inhibit translation of IL-3 mRNA in autocrine mast cell tumor lines. Cyclosporine 0-13 interleukin 3 Homo sapiens 144-148 9858612-2 1999 Cyclosporin A (CsA), a calcineurin antagonist and blocker of interleukin-2 (IL-2) transcription in T cells, was found to inhibit translation of IL-3 mRNA in autocrine mast cell tumor lines. Cyclosporine 15-18 interleukin 3 Homo sapiens 144-148 9858612-5 1999 The translational inhibition by CsA was specific to oncogenically induced lymphokines IL-3 and IL-4 but not to IL-6, c-jun, and c-myc, which are expressed in the nonmalignant precursor cells. Cyclosporine 32-35 interleukin 3 Homo sapiens 86-90 9020523-0 1997 The effects of cyclosporin A, dexamethasone and other immunomodulatory drugs on induced expression of IL-3, IL-4 and IL-8 mRNA in a human mast cell line. Cyclosporine 15-28 interleukin 3 Homo sapiens 102-106 9020523-3 1997 Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4. Cyclosporine 50-53 interleukin 3 Homo sapiens 135-139 9020523-3 1997 Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4. Cyclosporine 50-53 interleukin 3 Homo sapiens 236-240 9020523-4 1997 At both concentrations of CsA, expression of IL-3 was inhibited to a greater extent than that of the other two cytokines. Cyclosporine 26-29 interleukin 3 Homo sapiens 45-49 9020523-7 1997 In conclusion, this study shows that cytokine expression, particularly of IL-3, is inhibited in a human mast cell line by CsA and DEX. Cyclosporine 122-125 interleukin 3 Homo sapiens 74-78 8183344-0 1994 Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA. Cyclosporine 0-13 interleukin 3 Homo sapiens 78-91 7545487-1 1995 Cyclosporin A (CsA) inhibited interleukin 2 (IL-2), IL-3, interferon gamma (IFN gamma), GM-CSF and tumor necrosis factor alpha (TNF alpha) mRNA expression in spleen cells stimulated with concavalin A (Con A) when determined by the semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) method. Cyclosporine 0-13 interleukin 3 Homo sapiens 52-56 7545487-1 1995 Cyclosporin A (CsA) inhibited interleukin 2 (IL-2), IL-3, interferon gamma (IFN gamma), GM-CSF and tumor necrosis factor alpha (TNF alpha) mRNA expression in spleen cells stimulated with concavalin A (Con A) when determined by the semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) method. Cyclosporine 15-18 interleukin 3 Homo sapiens 52-56 7613145-3 1995 The immunosuppressive agents CsA and FK506 enhanced the release of leukotriene B4 (LTB4) from human neutrophil granulocytes dependent on the priming with G-CSF and IL-3. Cyclosporine 29-32 interleukin 3 Homo sapiens 164-168 7602099-2 1995 In humans, the GM-CSF and IL-3 genes are regulated by a cyclosporin A-inhibitable enhancer located 3 kb upstream of the GM-CSF gene that is inducible by signals that mimic TCR activation. Cyclosporine 56-69 interleukin 3 Homo sapiens 26-30 8183344-6 1994 Transcripts from exogenous IL-3 genes lacking the (A+U)-rich element (ARE) in the 3" untranslated terminal repeat could not be destabilized, suggesting that at least part of this sequence, which is known to mediate decay of short-lived mRNA, participates in a CsA-sensitive regulatory mechanism. Cyclosporine 260-263 interleukin 3 Homo sapiens 27-31 1706398-9 1991 IL-3 (3 and 10 ng/ml), but not IL-1 beta (10 and 100 ng/ml), reversed the inhibitory effect of both FK-506 and CsA on basophils challenged with anti-IgE or A23187. Cyclosporine 111-114 interleukin 3 Homo sapiens 0-4 7507316-6 1993 For instance, CsA and FK 506 inhibit the transcription of IL-3, IL-4, IFN gamma, TNF alpha or GM-CSF by activated T cells, and rapamycin has been shown to block the response to various growth factors such as IL-3, IL-4 or IL-6. Cyclosporine 14-17 interleukin 3 Homo sapiens 58-62 7507316-6 1993 For instance, CsA and FK 506 inhibit the transcription of IL-3, IL-4, IFN gamma, TNF alpha or GM-CSF by activated T cells, and rapamycin has been shown to block the response to various growth factors such as IL-3, IL-4 or IL-6. Cyclosporine 14-17 interleukin 3 Homo sapiens 208-212 8460159-1 1993 Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 3 (IL-3) are pleiotropic hemopoietic growth factors whose genes are closely linked and induced in T lymphocytes in a cyclosporin A (CsA)-sensitive fashion. Cyclosporine 191-204 interleukin 3 Homo sapiens 62-81 8460159-1 1993 Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 3 (IL-3) are pleiotropic hemopoietic growth factors whose genes are closely linked and induced in T lymphocytes in a cyclosporin A (CsA)-sensitive fashion. Cyclosporine 206-209 interleukin 3 Homo sapiens 62-81 8460159-3 1993 We located an inducible DNase I hypersensitive site, 3 kb upstream of the GM-CSF gene, that functioned as a strong CsA-sensitive enhancer of both the GM-CSF and IL-3 promoters. Cyclosporine 115-118 interleukin 3 Homo sapiens 161-165 8460159-7 1993 We propose that the intergenic enhancer described here is required for the correctly regulated activation of both GM-CSF and IL-3 gene expression in T cells and that it mediates the CsA sensitivity of the GM-CSF/IL-3 locus. Cyclosporine 182-185 interleukin 3 Homo sapiens 125-129 8460159-7 1993 We propose that the intergenic enhancer described here is required for the correctly regulated activation of both GM-CSF and IL-3 gene expression in T cells and that it mediates the CsA sensitivity of the GM-CSF/IL-3 locus. Cyclosporine 182-185 interleukin 3 Homo sapiens 212-216 1427430-1 1992 In this study we have analyzed the activity of Cyclosporin A (CsA) on the "in vitro" production of TNF and IL-3/GM-CSF as a preliminary basis for explaining the successful use of CsA in aplastic patients. Cyclosporine 62-65 interleukin 3 Homo sapiens 107-111 1427430-1 1992 In this study we have analyzed the activity of Cyclosporin A (CsA) on the "in vitro" production of TNF and IL-3/GM-CSF as a preliminary basis for explaining the successful use of CsA in aplastic patients. Cyclosporine 179-182 interleukin 3 Homo sapiens 107-111 1427430-5 1992 With these clones we studied the ability of CsA to inhibit TNF and IL-3/GM-CSF production, which was stimulated with specific monoclonal antibodies directed against the CD2 and CD3 surface antigens. Cyclosporine 44-47 interleukin 3 Homo sapiens 67-71 1427430-6 1992 TNF and IL-3/GM-CSF production displayed a different sensitivity to CsA inhibition. Cyclosporine 68-71 interleukin 3 Homo sapiens 8-12 1427430-7 1992 In fact, at 400 ng/ml CsA a residual production of IL-3/GM-CSF was present in all clones tested (CD3: 21.8% and CD2: 14.4% of the maximal IL-3/GM-CSF activity), while secretion of TNF was virtually abrogated at 100 ng/ml. Cyclosporine 22-25 interleukin 3 Homo sapiens 51-55 1427430-7 1992 In fact, at 400 ng/ml CsA a residual production of IL-3/GM-CSF was present in all clones tested (CD3: 21.8% and CD2: 14.4% of the maximal IL-3/GM-CSF activity), while secretion of TNF was virtually abrogated at 100 ng/ml. Cyclosporine 22-25 interleukin 3 Homo sapiens 138-142 1932305-1 1991 This case report describes the clinical use of recombinant human interleukin-3 as adjunct to immunosuppressive therapy with antilymphocyte globulin, cyclosporin A, and methylprednisolone for refractory severe aplastic anemia. Cyclosporine 149-162 interleukin 3 Homo sapiens 65-78 2974765-0 1988 Presence of an IL-3-producing suppressor T cell resistant to cyclosporin A in the peripheral blood of patients with systemic lupus erythematosus. Cyclosporine 61-74 interleukin 3 Homo sapiens 15-19 3495054-1 1987 Cyclosporine (CsA) inhibits release of interleukin 2 (IL-2) and hemopoietic growth activities such as interleukin 3 (IL-3) from major histocompatibility complex (MHC)-antigen-activated T cells. Cyclosporine 0-12 interleukin 3 Homo sapiens 102-121