PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18544910-3 2008 Acetylating pathway of INH to acetyl isoniazid (AcINH) tended to shift to the hydrolytic pathway generating hydrazine (Hz) with the increase of mutant alleles in NAT2 gene. hydrazine 108-117 N-acetyltransferase 2 Homo sapiens 162-166 18680467-9 2008 This analysis advances understanding of NAT2 structure-function relationships, important for interpreting the role of NAT2 genetic polymorphisms in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. hydrazine 198-207 N-acetyltransferase 2 Homo sapiens 40-44 18680467-9 2008 This analysis advances understanding of NAT2 structure-function relationships, important for interpreting the role of NAT2 genetic polymorphisms in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. hydrazine 198-207 N-acetyltransferase 2 Homo sapiens 118-122 21980537-1 2011 BACKGROUND: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. hydrazine 130-139 N-acetyltransferase 2 Homo sapiens 12-43 21980537-1 2011 BACKGROUND: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. hydrazine 130-139 N-acetyltransferase 2 Homo sapiens 45-49 18680467-1 2008 Arylamine N-acetyltransferase 2 (NAT2) modifies drug efficacy/toxicity and cancer risk due to its role in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. hydrazine 156-165 N-acetyltransferase 2 Homo sapiens 0-31 18680467-1 2008 Arylamine N-acetyltransferase 2 (NAT2) modifies drug efficacy/toxicity and cancer risk due to its role in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. hydrazine 156-165 N-acetyltransferase 2 Homo sapiens 33-37 7669073-1 1995 Arylamine N-acetyltransferase (NAT2) catalyses the N-acetylation of primary arylamine and hydrazine drugs and chemicals. hydrazine 90-99 N-acetyltransferase 2 Homo sapiens 31-35 17656365-1 2007 The human arylamine N-acetyltransferases NAT1 and NAT2 play an important role in the biotransformation of a plethora of aromatic amine and hydrazine drugs. hydrazine 139-148 N-acetyltransferase 2 Homo sapiens 50-54 15162844-2 2004 The N-acetyltransferase 2 (NAT2) acetylation polymorphism have been associated with a number of drug-induced toxicities and cancer in various tissues, resulting from decreased capacity to activate/deactivate several aromatic amine, hydrazine drugs, as well as HA carcinogens. hydrazine 232-241 N-acetyltransferase 2 Homo sapiens 4-25 15162844-2 2004 The N-acetyltransferase 2 (NAT2) acetylation polymorphism have been associated with a number of drug-induced toxicities and cancer in various tissues, resulting from decreased capacity to activate/deactivate several aromatic amine, hydrazine drugs, as well as HA carcinogens. hydrazine 232-241 N-acetyltransferase 2 Homo sapiens 27-31 9156695-1 1996 The hepatic N-acetyltransferase enzyme encoded by the NAT2* gene locus is responsible for the human polymorphic acetylation of numerous arylamine or hydrazine-containing drugs and xenobiotics including AIDS-related therapeutic agents such as isoniazid and sulphonamides. hydrazine 149-158 N-acetyltransferase 2 Homo sapiens 54-58 12715953-3 2003 Acetylation polymorphism relates to the metabolism of a number of arylamine and hydrazine drugs and carcinogens by cytosolic N-acetyltransferase--NAT2. hydrazine 80-89 N-acetyltransferase 2 Homo sapiens 146-150 11725342-7 2001 N-acetyltransferase 2 (NAT2), metabolizing xenobiotics with primary aromatic amine and hydrazine structures, is another important polymorphic phase II enzyme. hydrazine 87-96 N-acetyltransferase 2 Homo sapiens 0-21 11725342-7 2001 N-acetyltransferase 2 (NAT2), metabolizing xenobiotics with primary aromatic amine and hydrazine structures, is another important polymorphic phase II enzyme. hydrazine 87-96 N-acetyltransferase 2 Homo sapiens 23-27 33094670-1 2021 INTRODUCTION: The N-acetylation polymorphism has been the subject of comprehensive reviews describing the role of arylamine N-acetyltransferase 2 (NAT2) in the metabolism of numerous aromatic amine and hydrazine drugs. hydrazine 202-211 N-acetyltransferase 2 Homo sapiens 114-145 7929420-2 1994 The human arylamine N-acetyltransferases NAT1 and NAT2 catalyze the biotransformation of primary aromatic amine or hydrazine drugs and xenobiotics. hydrazine 115-124 N-acetyltransferase 2 Homo sapiens 50-54 1872889-4 1991 The second locus encodes an NAT which is termed polymorphic NAT (pNAT), has a distinct tissue distribution and is responsible for the difference in ability between individuals in acetylating certain arylamine (e.g. sulphamethazine) and hydrazine (e.g. isoniazid) drugs which are polymorphic substrates. hydrazine 236-245 N-acetyltransferase 2 Homo sapiens 48-63 1872889-4 1991 The second locus encodes an NAT which is termed polymorphic NAT (pNAT), has a distinct tissue distribution and is responsible for the difference in ability between individuals in acetylating certain arylamine (e.g. sulphamethazine) and hydrazine (e.g. isoniazid) drugs which are polymorphic substrates. hydrazine 236-245 N-acetyltransferase 2 Homo sapiens 65-69 33094670-1 2021 INTRODUCTION: The N-acetylation polymorphism has been the subject of comprehensive reviews describing the role of arylamine N-acetyltransferase 2 (NAT2) in the metabolism of numerous aromatic amine and hydrazine drugs. hydrazine 202-211 N-acetyltransferase 2 Homo sapiens 147-151 27853051-1 2017 Since NAT2 single-nucleotide polymorphisms (SNPs) are responsible for the efficacy of arylamines and hydrazine drugs, defining the effects of these SNPs in various ethnicities is an important factor in the development of personalized medicine. hydrazine 101-110 N-acetyltransferase 2 Homo sapiens 6-10 30149019-1 2018 N-acetyltransferase 2 (NAT2) catalyzes the biotransformation of numerous arylamine and hydrazine drugs and carcinogens. hydrazine 87-96 N-acetyltransferase 2 Homo sapiens 0-21 30149019-1 2018 N-acetyltransferase 2 (NAT2) catalyzes the biotransformation of numerous arylamine and hydrazine drugs and carcinogens. hydrazine 87-96 N-acetyltransferase 2 Homo sapiens 23-27 28523442-1 2017 Human N-acetyltransferase 2 (NAT2) catalyzes the N-acetylation of numerous aromatic amine drugs such as sulfamethazine (SMZ) and hydrazine drugs such as isoniazid (INH). hydrazine 129-138 N-acetyltransferase 2 Homo sapiens 6-27 28523442-1 2017 Human N-acetyltransferase 2 (NAT2) catalyzes the N-acetylation of numerous aromatic amine drugs such as sulfamethazine (SMZ) and hydrazine drugs such as isoniazid (INH). hydrazine 129-138 N-acetyltransferase 2 Homo sapiens 29-33 25005845-1 2014 N-Acetyltransferase 2 (NAT2) is a polymorphic gene encoding the enzyme that metabolizes arylamine and hydrazine moieties. hydrazine 102-111 N-acetyltransferase 2 Homo sapiens 0-21 25005845-1 2014 N-Acetyltransferase 2 (NAT2) is a polymorphic gene encoding the enzyme that metabolizes arylamine and hydrazine moieties. hydrazine 102-111 N-acetyltransferase 2 Homo sapiens 23-27